Anthrax lef cleaves target cell MAP2K6 (MEK6)

Stable Identifier
R-HSA-5211405
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
cytosol
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Anthrax lef cleaves target cell MAP2K6 (MEK6)
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lef (Anthrax LF, lethal factor) a zinc metalloprotease (Klimpel et al, 1994) in the target cell cytosol, cleaves MAP2K6 (MEK6, mitogen activated protein kinase kinase 6), isoform 1 (Vitale et al. 2000).

Literature References
PubMed ID Title Journal Year
7854123 Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

Klimpel, KR, Arora, N, Leppla, SH

Mol. Microbiol. 1994
11104681 Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor

Vitale, G, Bernardi, L, Napolitani, G, Mock, M, Montecucco, C

Biochem. J. 2000
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
proteolysis in other organism (0035897)
Catalyst Activity

metallopeptidase activity of lef [cytosol]

Physical Entity
lef [cytosol] (Bacillus anthracis)
Activity
metallopeptidase activity (GO:0008237)
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Liu, S  (2014-05-28)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Created
D'Eustachio, P  (2013-12-11)
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