Reactome | MAP2K6-1(15-334) [cytosol]

MAP2K6-1(15-334) [cytosol]

Stable Identifier

R-HSA-5211398

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MAP2K6-1 large LF fragment

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Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
11104681	Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor Mock, M, Napolitani, G, Montecucco, C, Bernardi, L, Vitale, G	Biochem. J.	2000

External Reference Information

External Reference

UniProt:P52564-1 MAP2K6

Gene Names

MAP2K6, MEK6, MKK6, PRKMK6, SKK3

Other Identifiers

11724606_a_at

11758909_at

1543_at

16837348

2014_s_at

205698_PM_s_at

205698_s_at

205699_PM_at

205699_at

229569_PM_at

229569_at

2844335

3725938

3733071

3733072

3733073

3733082

3733083

3733084

3733085

3733087

3733088

3733089

3733091

3733092

3733093

3733095

3733096

3733097

3733098

3733099

3733100

3733101

3733104

3733107

3733112

3733113

3733118

3733119

3733120

3733121

3733122

3733123

3733124

3733125

3733126

3733127

43958_at

5608

76095_at

7896243

7896639

8009476

83039_at

A_14_P106339

A_14_P130621

A_14_P201634

A_19_P00316010

A_19_P00812873

A_23_P207445

A_24_P416489

A_32_P44210

GE59129

GE608685

GE613227

GO:0000165

GO:0001649

GO:0002376

GO:0002931

GO:0003012

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006468

GO:0006915

GO:0007165

GO:0009410

GO:0012501

GO:0016740

GO:0019901

GO:0022414

GO:0022602

GO:0030154

GO:0031098

GO:0032308

GO:0035872

GO:0038066

GO:0042770

GO:0042802

GO:0043065

GO:0043226

GO:0043410

GO:0048856

GO:0051403

GO:0051726

GO:0051770

GO:0060048

GO:0060348

GO:0072709

GO:0090398

GO:0106310

GO:0120163

GO:0140096

GO:1901796

HMNXSV003039586

Hs.26017.0.A1_3p_at

ILMN_1660964

ILMN_1697729

PH_hs_0023282

PH_hs_0038755

TC17000807.hg

U39657_at

g10835026_3p_a_at

g1203817_3p_at

p7482

Participates

as an output of

Anthrax lef cleaves target cell MAP2K6 (MEK6) (Homo sapiens)

Other forms of this molecule

MAP2K6-1 [cytosol]

MAP2K6-1(1-14) [cytosol]

Disease

Name	Identifier	Synonyms
anthrax disease	DOID:7427

Cross References

RefSeq

NP_002749.2, XP_006722038.1, XP_011523329.1, NP_001317379.1, XP_005257573.1

ZINC - World Drugs

MP2K6_HUMAN

Guide to Pharmacology - Targets

2067

OpenTargets

ENSG00000108984

ENSEMBL

ENSP00000468348, ENST00000590474, ENSP00000467213, ENST00000589647

ZINC - FDA approved

MP2K6_HUMAN

ZINC - Substances

MP2K6_HUMAN

ZINC - Biogenic

MP2K6_HUMAN

ZINC target

P52564

PRO

P52564

GlyGen

P52564

PDB

3ENM, 5ETF, 3VN9, 8PM3, 8A8M, 2Y8O, 3FME, 8P7J

ZINC - Investigational

MP2K6_HUMAN

HPA

ENSG00000108984-MAP2K6

Pharos - Targets

P52564

ZINC - Predictions - Purchasable

MP2K6_HUMAN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.625	5
UniProt:P46734 MAP2K3	3	MAP2K3 [cytosol] (R-HSA-168051) p-S218,T222-MAP2K3 [cytosol] (R-HSA-167955) p-S218,T222-MAP2K3 [nucleoplasm] (R-HSA-450229)	0.615	3
UniProt:Q16539 MAPK14	7	MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.564	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.519	2
UniProt:Q9Y6R4 M3K4			0.519	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.463	4