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SIRT1 deacetylates TAF1B in SL1 complex
Stable Identifier
R-HSA-5211239
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
SIRT1 negatively regulates rRNA expression (Homo sapiens)
SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
As inferred from mouse, SIRT1, an NAD+ dependent deacetylase, deacetylates the TAF1B (TAF(1)68) subunit of the SL1 complex. Deacetylation of TAF1B inhibits transcription of rRNA genes.
Participants
Input
Acetylated SL1 [nucleoplasm]
(Homo sapiens)
NAD+ [nucleoplasm]
Output
2'-O-acetyl-ADP-ribose [nucleoplasm]
NAM [nucleoplasm]
SL1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
SIRT1 negatively regulates rRNA expression (Homo sapiens)
Catalyst Activity
NAD-dependent protein deacetylase activity of SIRT1 [nucleoplasm]
Physical Entity
SIRT1 [nucleoplasm]
(Homo sapiens)
Activity
NAD-dependent protein deacetylase activity (GO:0034979)
Inferred From
Sirt1 deacetylates Taf1b in SL1 complex (Mus musculus)
Authored
May, B (2013-11-15)
Reviewed
Voit, R (2014-01-21)
Grummt, I (2014-01-21)
Created
May, B (2013-12-09)
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