pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)

Stable Identifier
R-HSA-5210943
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
endosome membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Through the action of vacuolar ATPase the pH of the target cell early endosome is lowered. In this environment, paga (PA63, Anthrax protective antigen, large fragment) dissociates from its receptor and forms an oligomeric channel in the endosome membrane through which the anthrax cya (EF, edema factor) and lef (LF, lethal factor) pass (Milne et al. 1994). Entry of cya and lef into the target cell cytosol is thought to be mediated by back fusion of intraluminal vesicles with the late endosomal membrane and to be positively regulated by PDCD6IP / ALIX protein (Abrami et al. 2004).
Literature References
PubMed ID Title Journal Year
15337774 Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

Leppla, SH, Parton, RG, Lindsay, M, van der Goot, FG, Abrami, L

J. Cell Biol. 2004
8051159 Anthrax protective antigen forms oligomers during intoxication of mammalian cells

Milne, JC, Hanna, PC, Collier, RJ, Wall, JS, Furlong, D

J. Biol. Chem. 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein transmembrane transporter activity of cya:lef:(pagA(197-794):ANTXR2 oligomer) [endosome membrane]

Physical Entity
cya:lef:(pagA(197-794):ANTXR2 oligomer) [endosome membrane] (Homo sapiens)
Activity
protein transmembrane transporter activity (GO:0008320)
This event is regulated
Positively by
Regulator
H+ [endosome lumen]
Regulator
PDCD6IP [cytosol] (Homo sapiens)
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Liu, S  (2014-05-28)
Created
D'Eustachio, P  (2013-12-08)
Cite Us!