pagA binds ANTXR2

Stable Identifier
R-HSA-5210918
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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pagA binds ANTXR2
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Extracellular pagA (PA83, full length Protective Antigen - Petosa et al. 1997) produced by Bacillus anthracis binds to either of two isoforms of ANTXR2 (Anthrax Toxin Receptor 2, also known as CMG2 - Scobie et al. 2003) in the plasma membrane of a target human cell. The physiological ligand for ANTXR2 is not known, but this receptor has been shown to be the primary receptor involved in anthrax toxin pathogenesis (Liu et al. 2009). While some studies suggest that ANTXR2 is associated with palmitoylated LRP6 (low density lipoprotein receptor related protein 6 - Abrami et al. 2008) in the plasma membrane and that the latter protein can function as a co-receptor (Wei et al. 2006), the role of LRP6 in PA83 uptake remains uncertain (reviewed by van der Goot & Young 2009) and no function for LRP6 is annotated here.
Literature References
PubMed ID Title Journal Year
12700348 Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor

Young, JA, Scobie, HM, Rainey, GJ, Bradley, KA

Proc. Natl. Acad. Sci. U.S.A. 2003
9039918 Crystal structure of the anthrax toxin protective antigen

Klimpel, KR, Leppla, SH, Petosa, C, Collier, RJ, Liddington, RC

Nature 1997
18717822 Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6

van der Goot, FG, Abrami, L, Kunz, B, Davidson, G, Bafico, A, Deuquet, J

Cell. Microbiol. 2008
19732789 Receptors of anthrax toxin and cell entry

Young, JA, van der Goot, FG

Mol. Aspects Med. 2009
16564009 The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin

Lu, Q, Leppla, SH, Cohen, SN, Wei, W, Chaudry, GJ

Cell 2006
19617532 Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

Leppla, SH, Liu, S, Hu, H, Crown, D, Wang, H, Miller-Randolph, S, Morley, T, Moayeri, M

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Liu, S  (2014-05-28)
Created
D'Eustachio, P  (2013-12-07)
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