cya and lef bind to pagA(197-794):ANTXR2 oligomer

Stable Identifier
R-HSA-5210892
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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cya and lef bind to pagA(197-794):ANTXR2 oligomer
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The enzyme components of anthrax toxins cya (also known as EF, Edema Factor - Robertson et al. 1988) and lef (also known as LF, Lethal Factor - Bragg & Robertson 1989; Klimpel et al. 1994) bind to pagA(197-794):ANTXR2 (protective antigen, large fragment: Anthrax receptor 2) oligomers on the target cell surface. Binding of the two toxins to an oligomer is competitive and as many as four toxin molecules can bind to one oligomer (Elliott et al. 2000; Pimental et al. 2004).
Literature References
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Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Liu, S  (2014-05-28)
Created
D'Eustachio, P  (2013-12-07)
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