EF and LF bind to PA63:ANTXR2 oligomer

Stable Identifier
R-HSA-5210892
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
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The enzyme components of anthrax toxins EF (Edema Factor - Robertson et al. 1988) and LF (Lethal Factor - Bragg & Robertson 1989; Klimpel et al. 1994) bind to PA63:ANTXR2 (protective antigen, large fragment: Anthrax receptor 2) oligomers on the target cell surface. Binding of the two toxins to an oligomer is competitive and as many as four toxin molecules can bind to one oligomer (Elliott et al. 2000; Pimental et al. 2004).

Literature References
Participants
Participant Of
Disease
Name Identifier Synonyms
anthrax disease 7427
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