Reactome | 11c-retinyl-RHO [photoreceptor disc membrane]

11c-retinyl-RHO [photoreceptor disc membrane]

Stable Identifier

R-HSA-5205900

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

photoreceptor disc membrane

Synonyms

11-cis-retinyl-Rhodopsin, OPSD_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O95405 ZFYVE9

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External Reference Information

External Reference

UniProt:P08100 RHO

Gene Names

RHO, OPN2

Chain

chain:1-348

Reference Genes

BioGPS Gene:6010 RHO

COSMIC (genes):RHO RHO

CTD Gene:6010 RHO

dbSNP Gene:6010 RHO

ENSEMBL:ENSG00000163914 RHO

HGNC:10012 RHO

KEGG:hsa:6010 RHO

Monarch:6010 RHO

NCBI Gene:6010 RHO

OMIM:180380 RHO

UCSC:P08100 RHO

Reference Transcript

RefSeq:NM_000539.3 RHO

Other Identifiers

11743057_at

11743058_at

16945426

206454_PM_s_at

206454_s_at

206455_PM_s_at

206455_s_at

2641771

2641772

2641775

2641777

2641778

2641780

2641781

2641782

2641783

2641784

2641786

32875_at

32876_s_at

39524_at

6010

8082552

A_14_P136878

A_23_P57950

A_24_P26181

GE472471

GE900270

GO:0000139

GO:0000226

GO:0001750

GO:0001917

GO:0004930

GO:0005502

GO:0005515

GO:0005794

GO:0005886

GO:0005911

GO:0007010

GO:0007186

GO:0007601

GO:0007602

GO:0007603

GO:0008020

GO:0008289

GO:0009416

GO:0009583

GO:0009642

GO:0009881

GO:0010467

GO:0016020

GO:0016038

GO:0016056

GO:0030154

GO:0030660

GO:0042622

GO:0042995

GO:0043052

GO:0043226

GO:0045494

GO:0046872

GO:0048856

GO:0050877

GO:0050953

GO:0050960

GO:0060041

GO:0060089

GO:0060170

GO:0060342

GO:0065003

GO:0071482

GO:0071800

GO:0097225

GO:0097381

GO:0120200

GO:1904389

GO:1990913

HMNXSV003039902

Hs.247565.0.S1_3p_a_at

ILMN_1803871

PH_hs_0013100

TC03000693.hg

U49742_at

g7262389_3p_a_at

Participates

as an output of

11cRAL binds to opsin to form 11c-retinyl:RHO (Homo sapiens)

as an input of

Photons induce isomerization of 11c-retinyl to at-retinyl (Homo sapiens)

Other forms of this molecule

RHO [ciliary membrane]

RHO [Golgi-associated vesicle membrane]

RHO [Golgi membrane]

at-retinyl-RHO [photoreceptor disc membrane]

p-S334,338,343-at-retinyl-RHO [photoreceptor disc membrane]

p-S334,338,343-RHO [photoreceptor disc membrane]

RHO [photoreceptor disc membrane]

Inferred To

11c-retinyl-RHO [photoreceptor disc membrane] (Bos taurus)

11c-retinyl-RHO [photoreceptor disc membrane] (Caenorhabditis elegans)

11c-retinyl-RHO [photoreceptor disc membrane] (Canis familiaris)

11c-retinyl-RHO [photoreceptor disc membrane] (Gallus gallus)

11c-retinyl-RHO [photoreceptor disc membrane] (Mus musculus)

11c-retinyl-RHO [photoreceptor disc membrane] (Rattus norvegicus)

11c-retinyl-RHO [photoreceptor disc membrane] (Sus scrofa)

rho [photoreceptor disc membrane] (Danio rerio)

Modified Residues

Name

N6-(11-cis)-retinylidene-L-lysine (11c-retinyl group) at 296

Coordinate

296

Modification

11c-retinyl group

PsiMod Name

N6-(11-cis)-retinylidene-L-lysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-retinylidene-(11-cis)-L-lysine.

Cross References

Guide to Pharmacology - Targets

2963

ENSEMBL

ENSP00000296271, ENST00000296271

OpenTargets

ENSG00000163914

HPA

ENSG00000163914-RHO

PRO

P08100

Pharos - Targets

P08100

GlyGen

P08100

Orphanet

RHO

HMDB Protein

HMDBP02100

PDB

6CMO, 5DGY, 4ZWJ, 5W0P

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:O95405 ZFYVE9			0.544	2