CARM1 methylates arginine-18 (H3R17) of histone H3

Stable Identifier
R-HSA-5205822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CARM1 methylates arginine-18 of histone H3
Locations in the PathwayBrowser
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Coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) predominantly methylates histone H3 at arginine-18 (H3R17) (Ma et al. 2001, Bauer et al. 2002) and to a lesser extent arginine-27 (H3R26) (Schurter et al. 2001, Bauer et al. 2002). In vitro it can also methylate arginine-3, and one or more of four arginines (129/130/132/135) at the C-terminus (Schurter et al. 2001).

Literature References
PubMed ID Title Journal Year
11751582 Methylation at arginine 17 of histone H3 is linked to gene activation

Bauer, UM, Daujat, S, Nielsen, SJ, Nightingale, K, Kouzarides, T

EMBO Rep. 2002
11747826 Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter

Ma, H, Baumann, CT, Li, H, Strahl, BD, Rice, R, Jelinek, MA, Aswad, DW, Allis, CD, Hager, GL, Stallcup, MR

Curr. Biol. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein-arginine N-methyltransferase activity of CARM1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created