Parkin promotes the ubiquitination of mitochondrial substrates

Stable Identifier
R-HSA-5205682
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Locations in the PathwayBrowser
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Summation

Parkin promotes the ubiquitination of the mitofusin mitochondrial assembly regulatory factor (MARF), mitofusin 1, mitofusin 2 and voltage-dependent anion-selective channel protein 1 (vDAC1), all of which are embedded in the OMM.

Literature References
PubMed ID Title Journal Year
19432818 Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63

Sun, F, Kanthasamy, A, Anantharam, V, Kanthasamy, AG

J. Cell. Mol. Med. 2009
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of PARK2:PINK1 [mitochondrial outer membrane]
Physical Entity
PARK2:PINK1 [mitochondrial outer membrane]
Activity
ubiquitin-protein transferase activity (0004842)
Orthologous Events
Parkin promotes the ubiquitination of mitochondrial substrates (Bos taurus)
Parkin promotes the ubiquitination of mitochondrial substrates (Caenorhabditis elegans)
Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)
Parkin promotes the ubiquitination of mitochondrial substrates (Danio rerio)
Parkin promotes the ubiquitination of mitochondrial substrates (Drosophila melanogaster)
Parkin promotes the ubiquitination of mitochondrial substrates (Gallus gallus)
Parkin promotes the ubiquitination of mitochondrial substrates (Mus musculus)
Parkin promotes the ubiquitination of mitochondrial substrates (Rattus norvegicus)
Parkin promotes the ubiquitination of mitochondrial substrates (Taeniopygia guttata)
Authored
Gillespie, ME  (2013-11-21)
Reviewed
Chauss, D  (2015-09-01)
Kantorow, M  (2015-09-01)