Parkin promotes the ubiquitination of mitochondrial substrates

Stable Identifier
R-HSA-5205682
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial outer membrane
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Parkin promotes the ubiquitination of mitochondrial substrates
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Parkin promotes the ubiquitination of the mitofusin mitochondrial assembly regulatory factor (MARF), mitofusin 1, mitofusin 2 and voltage-dependent anion-selective channel protein 1 (vDAC1), all of which are embedded in the OMM.

Literature References
PubMed ID Title Journal Year
19432818 Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63

Kanthasamy, AG, Anantharam, V, Sun, F, Kanthasamy, A

J. Cell. Mol. Med. 2009
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of PARK2:PINK1 [mitochondrial outer membrane]

Physical Entity
PARK2:PINK1 [mitochondrial outer membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)
Parkin promotes the ubiquitination of mitochondrial substrates (Drosophila melanogaster)
Authored
Gillespie, ME  (2013-11-20)
Reviewed
Chauss, D  (2015-09-01)
Kantorow, M  (2015-09-01)
Created
Gillespie, ME  (2013-12-04)
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