Parkin promotes the ubiquitination of mitochondrial substrates

Stable Identifier
R-HSA-5205682
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Parkin promotes the ubiquitination of the mitofusin mitochondrial assembly regulatory factor (MARF), mitofusin 1, mitofusin 2 and voltage-dependent anion-selective channel protein 1 (vDAC1), all of which are embedded in the OMM.

Literature References
PubMed ID Title Journal Year
19432818 Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63

Sun, F, Kanthasamy, A, Anantharam, V, Kanthasamy, AG

J. Cell. Mol. Med. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of PARK2:PINK1 [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed