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K48polyUb-MFN1 [mitochondrial outer membrane]
Stable Identifier
R-HSA-5205679
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Mitofusin-1, MFN1_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN1 [mitochondrial outer membrane] (Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN1 [mitochondrial outer membrane] (Homo sapiens)
PRKN ubiquitinates MOM substrates (Homo sapiens)
PolyUb-MOM substrates of PRKN [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN1 [mitochondrial outer membrane] (Homo sapiens)
p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN1 [mitochondrial outer membrane] (Homo sapiens)
p62 links damaged mitochondria to LC3 (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN1 [mitochondrial outer membrane] (Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN1 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IWA4 MFN1
Gene Names
MFN1
Chain
chain:1-741
Reference Genes
BioGPS Gene:55669 MFN1
COSMIC (genes):MFN1 MFN1
CTD Gene:55669 MFN1
dbSNP Gene:55669 MFN1
ENSEMBL:ENSG00000171109 MFN1
HGNC:18262 MFN1
KEGG:hsa:55669 MFN1
Monarch:55669 MFN1
NCBI Gene:55669 MFN1
OMIM:608506 MFN1
UCSC:Q8IWA4 MFN1
Reference Transcript
RefSeq:NM_033540.2 MFN1
RefSeq:XM_005247596.3 MFN1
Other Identifiers
11731456_at
11731457_s_at
11755894_a_at
16948249
17125550
207098_PM_s_at
207098_s_at
211801_PM_x_at
211801_x_at
217043_PM_s_at
217043_s_at
2653933
2653934
2653937
2653938
2653940
2653941
2653942
2653944
2653945
2653946
2653947
2653948
2653949
2653952
2653954
2653955
2653956
2653957
2653958
2653959
2653960
2653961
2653962
2653963
2653964
2653969
2653970
2653971
2653972
2653973
2653974
2653978
2653980
2653982
38899_s_at
3986954
3986956
3986960
43500_at
55669
69284_at
8084045
A_14_P110354
A_14_P123996
A_23_P80648
GE63011
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005737
GO:0005739
GO:0005741
GO:0007005
GO:0008053
GO:0010918
GO:0016020
GO:0016787
GO:0042802
GO:0043226
GO:0046039
GO:0051646
GO:0055086
GO:0098799
GO:1901135
HMNXSV003009376
HMNXSV003048063
Hs.197877.3.A1_3p_a_at
ILMN_1664186
ILMN_1708959
PH_hs_0025289
TC03000953.hg
g12744895_3p_a_at
g8923620_3p_a_at
p12103
Participates
as a member of
K48polyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
p-S65-Ub:MFN1 [mitochondrial outer membrane]
K63polyUb-MFN1 [mitochondrial outer membrane]
Ub-MFN1 [mitochondrial outer membrane]
MFN1 [mitochondrial outer membrane]
Inferred To
K48polyUb-MFN1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
K48polyUb-MFN1 [mitochondrial outer membrane]
(Drosophila melanogaster)
K48polyUb-MFN1 [mitochondrial outer membrane]
(Gallus gallus)
K48polyUb-MFN1 [mitochondrial outer membrane]
(Mus musculus)
K48polyUb-MFN1 [mitochondrial outer membrane]
(Plasmodium falciparum)
K48polyUb-MFN1 [mitochondrial outer membrane]
(Rattus norvegicus)
K48polyUb-MFN1 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
K48polyUb-MFN1 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
MFN1 [mitochondrial outer membrane]
(Bos taurus)
MFN1 [mitochondrial outer membrane]
(Canis familiaris)
MFN1 [mitochondrial outer membrane]
(Sus scrofa)
mfn1 [mitochondrial outer membrane]
(Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at unknown position
Modification
K48-linked polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005247653.2
,
NP_284941.2
Guide to Pharmacology - Targets
3130
OpenTargets
ENSG00000171109
ENSEMBL
ENST00000263969
,
ENST00000471841
,
ENST00000357390
,
ENSP00000420617
,
ENSP00000349963
,
ENSP00000263969
HPA
ENSG00000171109-MFN1
PRO
Q8IWA4
Pharos - Targets
Q8IWA4
GlyGen
Q8IWA4
PDB
5GNU
,
5GOE
,
5GNS
,
5GO4
,
5GNR
,
5YEW
,
5GOM
,
5GNT
,
5GOF
HMDB Protein
HMDBP08481
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.527
2
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