Reactome | Uncleaved Pink1 accumulates in damaged mitochondria

Uncleaved Pink1 accumulates in damaged mitochondria

Stable Identifier

R-HSA-5205672

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

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Uncleaved Pink1 accumulates in damaged mitochondria

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On damaged mitochondria that have lost their membrane potential, however, PINK1 cleavage is inhibited, leading to high PINK1 protein accumulation on the inner leaf of the OMM of dysfunctional mitochondria. Full-length mitochondrial PINK1 is the active form in the PINK1/Parkin pathway.

Literature References

PubMed ID	Title	Journal	Year
21115803	Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL Jin, SM, Lazarou, M, Wang, C, Kane, LA, Narendra, DP, Youle, RJ	J. Cell Biol.	2010
20126261	PINK1 is selectively stabilized on impaired mitochondria to activate Parkin Narendra, DP, Jin, SM, Tanaka, A, Suen, DF, Gautier, CA, Shen, J, Cookson, MR, Youle, RJ	PLoS Biol.	2010
21194381	Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control Narendra, DP, Youle, RJ	Antioxid. Redox Signal.	2011