Uncleaved Pink1 accumulates in damaged mitochondria

Stable Identifier
R-HSA-5205672
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

On damaged mitochondria that have lost their membrane potential, however, PINK1 cleavage is inhibited, leading to high PINK1 protein accumulation on the inner leaf of the OMM of dysfunctional mitochondria. Full-length mitochondrial PINK1 is the active form in the PINK1/Parkin pathway.

Literature References
PubMed ID Title Journal Year
21115803 Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, SM, Lazarou, M, Wang, C, Kane, LA, Narendra, DP, Youle, RJ

J. Cell Biol. 2010
20126261 PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Narendra, DP, Jin, SM, Tanaka, A, Suen, DF, Gautier, CA, Shen, J, Cookson, MR, Youle, RJ

PLoS Biol. 2010
21194381 Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control

Narendra, DP, Youle, RJ

Antioxid. Redox Signal. 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created