On damaged mitochondria that have lost their membrane potential, however, PINK1 cleavage is inhibited, leading to high PINK1 protein accumulation on the inner leaf of the OMM of dysfunctional mitochondria. Full-length mitochondrial PINK1 is the active form in the PINK1/Parkin pathway.
Jin, SM, Lazarou, M, Wang, C, Kane, LA, Narendra, DP, Youle, RJ
Narendra, DP, Jin, SM, Tanaka, A, Suen, DF, Gautier, CA, Shen, J, Cookson, MR, Youle, RJ
Narendra, DP, Youle, RJ
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