Pink1 recruits Parkin to the outer mitochondrial membrane.

Stable Identifier
R-HSA-5205652
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Parkin promotes the ubiquitination of outer mitochondrial membrane emedded proteins including the mitofusin mitochondrial assembly regulatory factor (MARF), mitofusin 1, mitofusin 2 and voltage dependent anion selective channel protein 1 (vDAC1).

Literature References
PubMed ID Title Journal Year
20126261 PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Narendra, DP, Jin, SM, Tanaka, A, Suen, DF, Gautier, CA, Shen, J, Cookson, MR, Youle, RJ

PLoS Biol. 2010
Participants
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Orthologous Events
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