Reactome | K48polyUb-MTERFD1 [mitochondrial outer membrane]

K48polyUb-MTERFD1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-5205630

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

mTERF domain-containing protein 1, mitochondrial, MTER1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96E29 MTERF3

Gene Names

MTERF3, MTERFD1, CGI-12

Chain

transit peptide:1-68, chain:69-417

Reference Genes

BioGPS Gene:51001 MTERF3

COSMIC (genes):MTERF3 MTERF3

CTD Gene:51001 MTERF3

dbSNP Gene:51001 MTERF3

ENSEMBL:ENSG00000156469 MTERF3

ENSEMBL:ENSG00000156469.9 MTERF3

HGNC:24258 MTERF3

KEGG Gene (Homo sapiens):51001 MTERF3

Monarch:51001 MTERF3

NCBI Gene:51001 MTERF3

OMIM:616930 MTERF3

UCSC:Q96E29 MTERF3

Reference Transcript

RefSeq:NM_015942.4 MTERF3

Other Identifiers

11723347_a_at

17079380

219363_PM_s_at

219363_s_at

3145587

3145588

3145590

3145592

3145593

3145596

3145598

3145599

3145600

3145601

3145602

3145603

3145606

51001

62156_at

62157_s_at

8151917

A_24_P243834

GE58621

GO:0000976

GO:0003677

GO:0003690

GO:0005515

GO:0005739

GO:0005741

GO:0005829

GO:0006351

GO:0006355

GO:0006390

GO:0042254

GO:0043226

GO:0045892

GO:0061668

GO:0140053

HMNXSV003036865

ILMN_1782504

ILMN_2044617

PH_hs_0003311

TC08001451.hg

g7705587_3p_a_at

Participates

as an output of

Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)

as an input of

p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)

as a component of

K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

MTERFD1 [mitochondrial outer membrane]

Inferred To

K48polyUb-MTERFD1 [mitochondrial outer membrane] (Caenorhabditis elegans)

K48polyUb-MTERFD1 [mitochondrial outer membrane] (Canis familiaris)

K48polyUb-MTERFD1 [mitochondrial outer membrane] (Danio rerio)

K48polyUb-MTERFD1 [mitochondrial outer membrane] (Gallus gallus)

mTerf3 [mitochondrial outer membrane] (Drosophila melanogaster)

Mterf3 [mitochondrial outer membrane] (Mus musculus)

Mterf3 [mitochondrial outer membrane] (Rattus norvegicus)

MTERF3 [mitochondrial outer membrane] (Bos taurus)

MTERF3 [mitochondrial outer membrane] (Sus scrofa)

mterf3 [mitochondrial outer membrane] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at unknown position

Modification

K48-linked polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_057026.3

OpenTargets

ENSG00000156469

GeneCards

Q96E29

HPA

ENSG00000156469-MTERF3

Ensembl

ENST00000522822, ENSP00000287025, ENSP00000430138, ENSG00000156469, ENST00000287025

PRO

Q96E29

Pharos - Targets

Q96E29

PDB

3M66

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15041 AR6P1			0.556	3
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.556	3
UniProt:A8MV81 HIG1C			0.556	3
UniProt:Q9UGQ2 FLOWR			0.556	3
UniProt:Q8N9I5 FADS6			0.556	3
UniProt:P02654 APOC1	1	APOC1 [extracellular region] (R-HSA-8855541)	0.556	3
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.556	3
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q8IVQ6 ZDHHC21	1	ZDHHC21 [Golgi membrane] (R-HSA-203757)	0.556	3
UniProt:P22732 SLC2A5	2	SLC2A5 [plasma membrane] (R-HSA-189202) SLC2A5 [specific granule membrane] (R-HSA-6799571)	0.556	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.556	3
UniProt:Q969L2 MAL2			0.556	3
UniProt:Q96DZ9 CKLF5			0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:Q9UNK0 STX8			0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:O95159 ZFPL1			0.556	3
UniProt:Q9BYT1 S17A9			0.556	3
UniProt:Q9NPR9 GP108			0.556	3
UniProt:Q9BRV3 SLC50A1	1	SLC50A1 [plasma membrane] (R-HSA-5216211)	0.556	3
UniProt:Q9P0S9 TM14C			0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q9UHX3 ADGRE2	1	EMR2 [plasma membrane] (R-HSA-444760)	0.556	3
UniProt:O43759-2 SYNGR1			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q9UKR5 ERG28			0.556	3

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