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CFLAR(1-376) [cytosol]
Stable Identifier
R-HSA-51925
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CASP8 and FADD-like apoptosis regulator precursor, Cellular FLICE-like inhibitory protein, c-FLIP, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, MACH-related inducer of toxicity, MRIT, Caspase homolog, CASH, Inhibitor of FLICE, I-FLICE, FADD-like antiapoptotic molecule 1, Flame-1, Usurpin
Locations in the PathwayBrowser for interactor UniProt:P50591 TNFSF10
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TRAIL signaling (Homo sapiens)
TRAIL:TRAIL receptor trimers bind FADD (Homo sapiens)
CFLAR(1-376) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15519 CFLAR
Gene Names
CFLAR, CASH, CASP8AP1, CLARP, MRIT
Chain
chain:1-376, chain:377-480
Reference Genes
BioGPS Gene:8837 CFLAR
COSMIC (genes):CFLAR CFLAR
CTD Gene:8837 CFLAR
dbSNP Gene:8837 CFLAR
ENSEMBL:ENSG00000003402 CFLAR
HGNC:1876 CFLAR
KEGG:hsa:8837 CFLAR
Monarch:8837 CFLAR
NCBI Gene:8837 CFLAR
OMIM:603599 CFLAR
UCSC:O15519 CFLAR
Reference Transcript
RefSeq:NM_003879.5 CFLAR
RefSeq:XM_017005192.1 CFLAR
RefSeq:XM_017005196.1 CFLAR
RefSeq:NM_001202517.1 CFLAR
RefSeq:NM_001127184.2 CFLAR
RefSeq:XM_017005195.1 CFLAR
RefSeq:XM_017005198.1 CFLAR
RefSeq:NM_001202515.1 CFLAR
RefSeq:XM_017005190.1 CFLAR
RefSeq:NM_001202516.1 CFLAR
RefSeq:XM_017005194.1 CFLAR
RefSeq:NM_001202519.1 CFLAR
RefSeq:NM_001308042.1 CFLAR
RefSeq:XM_017005197.1 CFLAR
RefSeq:NM_001202518.1 CFLAR
RefSeq:XM_017005193.1 CFLAR
RefSeq:XM_017005191.1 CFLAR
RefSeq:NM_001127183.2 CFLAR
This entity regulates
Negatively
TRAIL:TRAIL receptor trimers bind FADD
(Homo sapiens)
Inferred To
CFLAR(1-376) [cytosol]
(Gallus gallus)
Cflar [cytosol]
(Mus musculus)
Cflar [cytosol]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000003402
ENSEMBL
ENST00000440180
,
ENST00000342795
,
ENSP00000339335
,
ENST00000341222
,
ENST00000479953
,
ENSP00000312455
,
ENSP00000413270
,
ENSP00000406775
,
ENST00000423241
,
ENSP00000342809
,
ENST00000309955
,
ENSP00000399420
,
ENST00000341582
,
ENST00000443227
,
ENST00000457277
,
ENSP00000471805
,
ENSP00000345807
,
ENSG00000003402
,
ENSP00000411535
HPA
ENSG00000003402-CFLAR
GeneCards
CFLAR
PRO
O15519
Pharos - Targets
O15519
PDB
8YD8
,
3H11
,
7LXC
,
6M6O
,
2N5R
,
8YD7
,
8YBX
,
3H13
,
7DEE
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14790 CASP8
8
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
0.744
10
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.718
6
UniProt:Q92851 CASP10
4
CASP10(1-521) [cytosol]
(R-HSA-933453)
CASP10(416-521) [cytosol]
(R-HSA-933455)
CASP10(1-219) [cytosol]
(R-HSA-933454)
CASP10(220-415) [cytosol]
(R-HSA-933458)
0.65
3
UniProt:P50591 TNFSF10
1
TNFSF10 [extracellular region]
(R-HSA-66186)
0.527
2
UniProt:Q00G26 PLIN5
0.527
2
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