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CDK9 [nucleoplasm]
Stable Identifier
R-HSA-51801
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdk 9 protein, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, C-2K, Cell division protein kinase 9
Locations in the PathwayBrowser for interactor UniProt:Q8WXE1 ATRIP
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Tat with host cellular proteins (Homo sapiens)
Formation of the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
CDK9 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
Formation of P-TEFb complex (Homo sapiens)
CDK9 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50750 CDK9
Gene Names
CDK9, CDC2L4, TAK
Chain
chain:1-372
Reference Genes
BioGPS Gene:1025 CDK9
COSMIC (genes):CDK9 CDK9
CTD Gene:1025 CDK9
dbSNP Gene:1025 CDK9
ENSEMBL:ENSG00000136807 CDK9
ENSEMBL_homo_sapiens_GENE:ENSG00000136807.14 CDK9
HGNC:1780 CDK9
KEGG Gene (Homo sapiens):1025 CDK9
Monarch:1025 CDK9
NCBI Gene:1025 CDK9
OMIM:603251 CDK9
UCSC:P50750 CDK9
Reference Transcript
RefSeq:NM_001261.3 CDK9
Other Identifiers
1025
11720659_at
11720660_s_at
11720661_at
17089446
17119724
203198_PM_at
203198_at
236023_PM_at
236023_at
3190039
3190040
3190041
3190042
3190044
3190045
3190047
3190048
3190051
3190052
3190053
3190054
3190055
3190056
3190057
3190058
387_at
62680_at
8158112
A_14_P113061
A_23_P169470
A_32_P309929
GE79527
GO:0000166
GO:0000976
GO:0000978
GO:0001223
GO:0003677
GO:0003682
GO:0003723
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0006260
GO:0006281
GO:0006282
GO:0006325
GO:0006351
GO:0006355
GO:0006366
GO:0006367
GO:0006368
GO:0006468
GO:0006974
GO:0008023
GO:0008024
GO:0008283
GO:0008353
GO:0016020
GO:0016071
GO:0016301
GO:0016310
GO:0016605
GO:0016740
GO:0017069
GO:0019901
GO:0030154
GO:0031297
GO:0031440
GO:0032968
GO:0036211
GO:0036464
GO:0043226
GO:0043923
GO:0045944
GO:0048856
GO:0051147
GO:0051647
GO:0051726
GO:0070691
GO:0071345
GO:0097322
GO:0106310
GO:0120186
GO:0120187
GO:0140096
GO:0140673
HMNXSV003003121
HMNXSV003051590
Hs.182907.0.A1_3p_at
ILMN_1747556
PH_hs_0009057
TC09000671.hg
X80230_at
g4502746_3p_at
Participates
as an input of
Formation of P-TEFb complex (Homo sapiens)
Formation of the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
as a component of
P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Homo sapiens)
P-TEFb complex [nucleoplasm] (Homo sapiens)
Inferred To
CDK9 [nucleoplasm]
(Bos taurus)
CDK9 [nucleoplasm]
(Caenorhabditis elegans)
CDK9 [nucleoplasm]
(Canis familiaris)
CDK9 [nucleoplasm]
(Danio rerio)
CDK9 [nucleoplasm]
(Dictyostelium discoideum)
CDK9 [nucleoplasm]
(Drosophila melanogaster)
CDK9 [nucleoplasm]
(Gallus gallus)
CDK9 [nucleoplasm]
(Mus musculus)
CDK9 [nucleoplasm]
(Plasmodium falciparum)
CDK9 [nucleoplasm]
(Rattus norvegicus)
CDK9 [nucleoplasm]
(Saccharomyces cerevisiae)
CDK9 [nucleoplasm]
(Schizosaccharomyces pombe)
CDK9 [nucleoplasm]
(Sus scrofa)
CDK9 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001252.1
ZINC - World Drugs
CDK9_HUMAN
Guide to Pharmacology - Targets
1981
OpenTargets
ENSG00000136807
ZINC - FDA approved
CDK9_HUMAN
ZINC - Substances
CDK9_HUMAN
ZINC target
P50750
ZINC - Biogenic
CDK9_HUMAN
PRO
P50750
PDB
6Z45
,
4IMY
,
3MY1
,
3LQ5
,
6CYT
,
3TN8
,
3TNI
,
4BCG
,
8K5R
,
5L1Z
,
3TNH
,
4BCF
,
4OGR
,
3MI9
,
4OR5
,
4BCJ
,
4EC9
,
6W9E
,
4BCI
,
4EC8
,
4BCH
,
3BLH
,
7NWK
,
3MIA
,
8I0L
,
6GZH
,
3BLR
,
3BLQ
ZINC - Investigational
CDK9_HUMAN
IntEnz
2.7.11.22
GeneCards
P50750
HPA
ENSG00000136807-CDK9
Ensembl
ENSP00000362361
,
ENST00000373264
,
ENSG00000136807
Pharos - Targets
P50750
Orphanet
29617
ZINC - Predictions - Purchasable
CDK9_HUMAN
HMDB Protein
HMDBP01360
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60563 CCNT1
1
CCNT1 [nucleoplasm]
(R-HSA-51611)
0.977
31
UniProt:O94992 HEXI1
0.929
17
UniProt:Q4G0J3 LARP7
0.929
18
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.899
10
UniProt:O60583 CCNT2
1
CCNT2 [nucleoplasm]
(R-HSA-51613)
0.899
10
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.886
9
UniProt:P51825 AFF1
0.87
15
UniProt:Q9UHB7 AFF4
1
AFF4 [nucleoplasm]
(R-HSA-8932788)
0.87
12
UniProt:Q7L2J0 MEPCE
0.837
8
UniProt:Q03111 MLLT1
1
MLLT1 [nucleoplasm]
(R-HSA-8932918)
0.788
7
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.744
6
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.744
6
UniProt:P04608 tat
1
Tat (P04608) [nucleoplasm]
(R-HIV-175856)
0.737
8
UniProt:Q96MH2 HEXI2
0.725
6
UniProt:P51826 AFF3
0.725
5
UniProt:P42568 MLLT3
1
MLLT3 [nucleoplasm]
(R-HSA-8932789)
0.725
6
UniProt:O60885-1 BRD4
0.656
9
UniProt:Q9NYV4 CDK12
1
CDK12 [nucleoplasm]
(R-HSA-6797012)
0.643
3
UniProt:O00170 AIP
2
AIP [cytosol]
(R-HSA-8936839)
AIP [nucleoplasm]
(R-HSA-8937156)
0.643
5
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.564
2
UniProt:Q8WXE1 ATRIP
1
ATRIP [nucleoplasm]
(R-HSA-176231)
0.558
3
UniProt:Q9HAW4 CLSPN
5
PolyUb-CLSPN [nucleoplasm]
(R-HSA-6783087)
CLSPN(1-1072) [nucleoplasm]
(R-HSA-351929)
CLSPN(1073-1332) [nucleoplasm]
(R-HSA-351935)
CLSPN [nucleoplasm]
(R-HSA-176282)
p-T916,S945-CLSPN [nucleoplasm]
(R-HSA-176296)
0.558
3
UniProt:Q13535 ATR
1
ATR [nucleoplasm]
(R-HSA-912443)
0.558
3
UniProt:Q6NYC1 JMJD6
1
JMJD6 [nucleoplasm]
(R-HSA-4754226)
0.544
5
UniProt:P53041 PPP5C
2
PPP5C [cytosol]
(R-HSA-5675402)
PPP5C [nucleoplasm]
(R-HSA-5683410)
0.539
3
UniProt:Q6PD62 CTR9
1
CTR9 [nucleoplasm]
(R-HSA-8866694)
0.527
2
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.527
4
UniProt:O60583-1 CCNT2
0.499
3
UniProt:O60583-2 CCNT2
0.499
2
UniProt:Q9UPN9 TRIM33
1
TRIM33 [nucleoplasm]
(R-HSA-870522)
0.462
3
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.462
3
UniProt:P17542 TAL1
1
TAL1 [nucleoplasm]
(R-HSA-8956511)
0.462
3
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