p-S318,221-HuR binds mRNA

Stable Identifier
R-HSA-517705
Type
Reaction [binding]
Species
Homo sapiens
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HuR phosphorylated on ser221 and ser318 binds AU-rich regions of mRNAs. Phosphorylation on ser318 appears to affect RNA binding and phosphorylation of ser221 affects nucleocytoplasmic shuttling.

Literature References
PubMed ID Title Journal Year
18285462 Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA

Doller, A, Akool, el-S, Huwiler, A, Müller, R, Radeke, HH, Pfeilschifter, J, Eberhardt, W

Mol Cell Biol 2008
20086103 Tandem phosphorylation of serine 221 and 318 by PKC{delta} coordinates mRNA binding and nucleo-cytoplasmic shuttling of HuR

Doller, A, Schlepckow, K, Schwalbe, H, Pfeilschifter, J, Eberhardt, W

Mol Cell Biol 2010
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