Reactome | p-S318,221-HuR binds mRNA

p-S318,221-HuR binds mRNA

Stable Identifier

R-HSA-517705

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

HuR phosphorylated on ser221 and ser318 binds AU-rich regions of mRNAs. Phosphorylation on ser318 appears to affect RNA binding and phosphorylation of ser221 affects nucleocytoplasmic shuttling.

Literature References

PubMed ID	Title	Journal	Year
20086103	Tandem phosphorylation of serine 221 and 318 by PKC{delta} coordinates mRNA binding and nucleo-cytoplasmic shuttling of HuR Pfeilschifter, J, Doller, A, Schwalbe, H, Schlepckow, K, Eberhardt, W	Mol Cell Biol	2010
18285462	Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA Pfeilschifter, J, Müller, R, Doller, A, Huwiler, A, Akool, el-S, Eberhardt, W, Radeke, HH	Mol Cell Biol	2008