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GPR18 [plasma membrane]
Stable Identifier
R-HSA-517529
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
N-arachidonyl glycine receptor, GPR18_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR18:NAGLY [plasma membrane] (Homo sapiens)
GPR18 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR18:NAGLY [plasma membrane] (Homo sapiens)
GPR18 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR18:NAGLY [plasma membrane] (Homo sapiens)
GPR18 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR18:NAGLY [plasma membrane] (Homo sapiens)
GPR18 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR18:NAGLY [plasma membrane] (Homo sapiens)
GPR18 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR18:NAGLY [plasma membrane] (Homo sapiens)
GPR18 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Homo sapiens)
GPR18 [plasma membrane] (Homo sapiens)
GPR18:NAGLY [plasma membrane] (Homo sapiens)
GPR18 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14330 GPR18
Gene Names
GPR18, GPCRW
Chain
chain:1-331
Reference Genes
BioGPS Gene:2841 GPR18
COSMIC (genes):GPR18 GPR18
CTD Gene:2841 GPR18
dbSNP Gene:2841 GPR18
ENSEMBL:ENSG00000125245 GPR18
HGNC:4472 GPR18
KEGG:hsa:2841 GPR18
Monarch:2841 GPR18
NCBI Gene:2841 GPR18
OMIM:602042 GPR18
UCSC:Q14330 GPR18
Reference Transcript
RefSeq:NM_001098200.1 GPR18
RefSeq:NM_005292.3 GPR18
RefSeq:XM_006719946.3 GPR18
Other Identifiers
11732544_a_at
11734273_s_at
16780585
210279_PM_at
210279_at
252_at
253_g_at
2841
3522645
3522646
3522647
3522648
3522649
3522650
3522651
3522652
3522653
54353_at
7972548
A_23_P14165
GE62470
GO:0002300
GO:0002305
GO:0002376
GO:0002689
GO:0004930
GO:0005886
GO:0007165
GO:0007186
GO:0007200
GO:0016020
GO:0030154
GO:0030659
GO:0031410
GO:0032720
GO:0035025
GO:0043226
GO:0060089
HMNXSV003001641
ILMN_1780368
L42324_at
PH_hs_0004944
TC13000828.hg
g12005919_3p_at
Participates
as an input of
N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Homo sapiens)
as a component of
GPR18:NAGLY [plasma membrane] (Homo sapiens)
Inferred To
gpr18 [plasma membrane]
(Xenopus tropicalis)
Gpr18 [plasma membrane]
(Mus musculus)
Gpr18 [plasma membrane]
(Rattus norvegicus)
GPR18 [plasma membrane]
(Bos taurus)
GPR18 [plasma membrane]
(Canis familiaris)
GPR18 [plasma membrane]
(Gallus gallus)
GPR18 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_006720009.1
,
NP_001091670.1
,
NP_005283.1
Guide to Pharmacology - Targets
89
ENSEMBL
ENSP00000401611
,
ENST00000397473
,
ENSP00000343428
,
ENSP00000380613
,
ENSP00000380610
,
ENST00000340807
,
ENST00000416594
,
ENSG00000125245
,
ENST00000397470
OpenTargets
ENSG00000125245
ZINC - FDA approved
GPR18_HUMAN
ZINC - Substances
GPR18_HUMAN
ZINC - Biogenic
GPR18_HUMAN
ZINC target
Q14330
PRO
Q14330
GlyGen
Q14330
GeneCards
GPR18
HPA
ENSG00000125245-GPR18
Pharos - Targets
Q14330
ZINC - Predictions - Purchasable
GPR18_HUMAN
HMDB Protein
HMDBP10738
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P36952 SPB5
0.527
2
UniProt:Q9NZT1 CALML5
3
CALML5 [cytosol]
(R-HSA-9839523)
CALML5 [extracellular region]
(R-HSA-6806470)
CALML5 [ficolin-1-rich granule lumen]
(R-HSA-6801291)
0.527
2
UniProt:P48594 SPB4
0.527
2
UniProt:P29508 SERPINB3
2
SERPINB3 [extracellular region]
(R-HSA-6806189)
SERPINB3 [azurophil granule lumen]
(R-HSA-6799340)
0.527
2
UniProt:P42357 HAL
1
HAL [cytosol]
(R-HSA-70897)
0.527
2
UniProt:P30838 ALDH3A1
1
ALDH3A1 [cytosol]
(R-HSA-5692291)
0.527
2
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