Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP and NADPH + H+ to yield IMP and NADP+ + NH4+ (Spector et al. 1979; Deng et al. 2002). Two GMPR proteins have been identified, GMPR and GMPR2. Both proteins form homotetramers (GMPR - unpublished crstallographic data PDB 2BLE; GMPR2 - Li et al. 2006).
Miller, RL, Jones, TE, Spector, T
Gu, S, Deng, Y, Wang, Y, Huang, Y, Ying, K, Gu, X, Xie, Y, Mao, Y, Ji, C, Xu, Y, Li, Y, Wang, Z
Deng, Y, Qiu, R, Gu, X, Chen, F, Li, J, Xie, Y, Wei, Z, Mao, Y, Gong, W, Ji, C, Zheng, M
GMP reductase activity of GMPR tetramers [cytosol]
© 2021 Reactome
