GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

Stable Identifier
R-HSA-514604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP and NADPH + H+ to yield IMP and NADP+ + NH4+ (Spector et al. 1979; Deng et al. 2002). Two GMPR proteins have been identified, GMPR and GMPR2. Both proteins form homotetramers (GMPR - unpublished crstallographic data PDB 2BLE; GMPR2 - Li et al. 2006).

Literature References
PubMed ID Title Journal Year
218932 Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators

Miller, RL, Jones, TE, Spector, T

J Biol Chem 1979
12009299 NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties

Gu, S, Deng, Y, Wang, Y, Huang, Y, Ying, K, Gu, X, Xie, Y, Mao, Y, Ji, C, Xu, Y, Li, Y, Wang, Z

Int J Biochem Cell Biol 2002
16359702 Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP

Deng, Y, Qiu, R, Gu, X, Chen, F, Li, J, Xie, Y, Wei, Z, Mao, Y, Gong, W, Ji, C, Zheng, M

J Mol Biol 2006
Participants
Participates
Catalyst Activity

GMP reductase activity of GMPR tetramers [cytosol]

Orthologous Events
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