Reactome | GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

Stable Identifier

R-HSA-514604

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

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Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP and NADPH + H+ to yield IMP and NADP+ + NH4+ (Spector et al. 1979; Deng et al. 2002). Two GMPR proteins have been identified, GMPR and GMPR2. Both proteins form homotetramers (GMPR - unpublished crstallographic data PDB 2BLE; GMPR2 - Li et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12009299	NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties Deng, Y, Wang, Z, Ying, K, Gu, S, Ji, C, Huang, Y, Gu, X, Wang, Y, Xu, Y, Li, Y, Xie, Y, Mao, Y	Int J Biochem Cell Biol	2002
16359702	Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP Li, J, Wei, Z, Zheng, M, Gu, X, Deng, Y, Qiu, R, Chen, F, Ji, C, Gong, W, Xie, Y, Mao, Y	J Mol Biol	2006
218932	Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators Spector, T, Jones, TE, Miller, RL	J Biol Chem	1979