WNT5A-FZD4 recruits DVL2

Stable Identifier
R-HSA-5138441
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
WNT5A-FZD4 recruits DVL2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

DVL2 is recruited to the WNT5A:FZD4 receptor complex as assessed by co-localization and co-immunoprecipitation (Chen et al, 2003).

Literature References
PubMed ID Title Journal Year
12958364 Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

Chen, W, ten Berge, D, Brown, J, Ahn, S, Hu, LA, Miller, WE, Caron, MG, Barak, LS, Nusse, R, Lefkowitz, RJ

Science 2003
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
WNT5A-FZD4 recruits DVL2 (Bos taurus)
WNT5A-FZD4 recruits DVL2 (Caenorhabditis elegans)
WNT5A-FZD4 recruits DVL2 (Canis familiaris)
WNT5A-FZD4 recruits DVL2 (Danio rerio)
WNT5A-FZD4 recruits DVL2 (Drosophila melanogaster)
WNT5A-FZD4 recruits DVL2 (Mus musculus)
WNT5A-FZD4 recruits DVL2 (Rattus norvegicus)
WNT5A-FZD4 recruits DVL2 (Sus scrofa)
Authored
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-11-15)