Reactome | alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate

alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate

Stable Identifier

R-HSA-508561

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate

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Kynurenine/alpha-aminoadipate aminotransferase (AADAT) catalyzes the reversible reaction of alpha-ketoadipate and glutamate to form alpha-aminoadipate and alpha-ketoglutarate. Crystallographic studies have demonstrated that active AADAT enzyme is a homodimer with a pyridoxal phosphate moiety covalently attached to each monomer (Han et al. 2008; Rossi et al. 2008). The enzyme is inferred to be located within the mitochondrion because of a mitochondrial localization sequence motif at the aminoterminal end of the AADAT polypeptide (Goh et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
18056995	Crystal structure of human kynurenine aminotransferase II Robinson, H, Li, J, Han, Q	J Biol Chem	2008
18056996	Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia Montalbano, V, Garavaglia, S, Rizzi, M, Walsh, MA, Rossi, F	J Biol Chem	2008
12126930	Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). Geraghty, MT, Salomons, GS, Schor, DS, Patel, A, Thomas, GH, Jakobs, C, Goh, DL	Mol Genet Metab	2002