Reactome | PTK2B binds JAK3

PTK2B binds JAK3

Stable Identifier

R-HSA-508513

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Pyk2 associates with Jak3

ReviewStatus

5/5

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The proline-rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko 2005).
Coimmunoprecipitation experiments have demonstrated a physical association of Jak3 and Pyk2. A dominant interfering mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation. Collectively, these results suggest that Pyk2 is a component of the Jak-mediated IL-2 signaling pathway, but a role has not been firmly established.

Literature References

PubMed ID	Title	Journal	Year
9512511	Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway Miyazaki, T, Takaoka, A, Nogueira, L, Dikic, I, Fujii, H, Tsujino, S, Mitani, Y, Maeda, M, Schlessinger, J, Taniguchi, T	Genes Dev	1998