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ACE(30-1306) [plasma membrane]
Stable Identifier
R-HSA-508496
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ACE, Angiotensin-converting enzyme, ACE_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Metabolism of Angiotensinogen to Angiotensins (Homo sapiens)
ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
ACE(30-1306):Zn2+ [plasma membrane] (Homo sapiens)
ACE(30-1306) [plasma membrane] (Homo sapiens)
ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Homo sapiens)
ACE(30-1306):Zn2+ [plasma membrane] (Homo sapiens)
ACE(30-1306) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12821 ACE
Gene Names
ACE, DCP, DCP1
Chain
signal peptide:1-29, chain:30-1306, chain:30-1232
Reference Genes
BioGPS Gene:1636 ACE
COSMIC (genes):ACE ACE
CTD Gene:1636 ACE
dbSNP Gene:1636 ACE
ENSEMBL:ENSG00000159640 ACE
HGNC:2707 ACE
KEGG:hsa:1636 ACE
Monarch:1636 ACE
NCBI Gene:1636 ACE
UCSC:P12821 ACE
Reference Transcript
RefSeq:NM_000789.3 ACE
RefSeq:NM_001178057.1 ACE
RefSeq:NM_152830.2 ACE
Other Identifiers
11737789_a_at
11744189_a_at
11752871_a_at
11761789_at
1636
16836896
209749_PM_s_at
209749_s_at
227463_PM_at
227463_at
37013_at
3730605
3730606
3730607
3730608
3730609
3730610
3730611
3730612
3730613
3730614
3730615
3730616
3730617
3730618
3730619
3730620
3730621
3730622
3730623
3730624
3730625
3730626
3730627
3730628
3730629
3730630
3730631
3730632
3730633
3730634
3730635
3730636
3730637
3730638
3730639
3730640
3730641
3730642
3730643
3730644
3730645
3730646
3730647
3730648
3730649
3730650
3730651
3730652
3730653
3730654
3730655
3730656
3730657
59504_at
77403_at
A_14_P128356
A_23_P38235
A_24_P365129
A_33_P3229288
GE80101
GE84219
GO:0001666
GO:0001822
GO:0001974
GO:0002003
GO:0002019
GO:0002376
GO:0002446
GO:0002474
GO:0003013
GO:0003081
GO:0003084
GO:0003779
GO:0003824
GO:0004175
GO:0004180
GO:0004222
GO:0005515
GO:0005516
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005886
GO:0006508
GO:0006518
GO:0007283
GO:0007565
GO:0008092
GO:0008217
GO:0008233
GO:0008237
GO:0008238
GO:0008240
GO:0008241
GO:0008270
GO:0008584
GO:0009410
GO:0009792
GO:0009897
GO:0009925
GO:0010608
GO:0010629
GO:0010814
GO:0010815
GO:0014910
GO:0016020
GO:0016787
GO:0019229
GO:0022414
GO:0030154
GO:0030324
GO:0031100
GO:0031404
GO:0031410
GO:0031434
GO:0031526
GO:0031667
GO:0031711
GO:0031982
GO:0032496
GO:0032943
GO:0034616
GO:0038166
GO:0042310
GO:0042445
GO:0042447
GO:0042755
GO:0043065
GO:0043171
GO:0043226
GO:0045777
GO:0045907
GO:0046325
GO:0046872
GO:0048167
GO:0048286
GO:0048856
GO:0050435
GO:0050482
GO:0050769
GO:0050886
GO:0051019
GO:0051604
GO:0060047
GO:0060177
GO:0060218
GO:0060978
GO:0070062
GO:0070573
GO:0071333
GO:0071548
GO:0071838
GO:0086091
GO:0090281
GO:0097066
GO:0097225
GO:0097746
GO:0140096
GO:1901363
GO:1902033
GO:1903597
GO:1904045
GO:2000170
HMNXSV003034454
Hs.126900.0.A1_3p_at
Hs.298469.1.S1_3p_s_at
ILMN_1779984
ILMN_2339410
M26657_s_at
Participates
as a component of
ACE(30-1306):Zn2+ [plasma membrane] (Homo sapiens)
Other forms of this molecule
ACE(30-1232) [extracellular region]
Inferred To
ACE(30-1306) [plasma membrane]
(Bos taurus)
ACE(30-1306) [plasma membrane]
(Drosophila melanogaster)
ACE(30-1306) [plasma membrane]
(Gallus gallus)
ACE(30-1306) [plasma membrane]
(Mus musculus)
ACE(30-1306) [plasma membrane]
(Rattus norvegicus)
ACE(30-1306) [plasma membrane]
(Sus scrofa)
Ance-5 [plasma membrane]
(Drosophila melanogaster)
Ance-3 [plasma membrane]
(Drosophila melanogaster)
ACE [plasma membrane]
(Canis familiaris)
Ance-2 [plasma membrane]
(Drosophila melanogaster)
ace [plasma membrane]
(Xenopus tropicalis)
Homologues of ACE(30-1306) [plasma membrane]
(Drosophila melanogaster)
acn-1 [plasma membrane]
(Caenorhabditis elegans)
Ance-4 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_690043.1
,
NP_001171528.1
,
NP_000780.1
ZINC - World Drugs
ACE_HUMAN
Guide to Pharmacology - Targets
1613
OpenTargets
ENSG00000159640
ENSEMBL
ENSP00000290863
,
ENST00000290863
,
ENST00000290866
,
ENSP00000392247
,
ENST00000413513
,
ENSP00000290866
ZINC - FDA approved
ACE_HUMAN
ZINC - Substances
ACE_HUMAN
ZINC - Biogenic
ACE_HUMAN
ZINC target
P12821
PRO
P12821
PDB
2OC2
,
1UZF
,
4CA6
,
6ZPU
,
5AMA
,
2C6N
,
6EN6
,
2IUL
,
2IUX
,
6F9T
,
6TT4
,
4C2Q
,
3BKL
,
4UFB
,
7Q4D
,
3BKK
,
7Q27
,
2C6F
,
6H5W
,
6F9V
,
8QFX
,
7Q3Y
,
3L3N
,
4C2O
,
6TT3
,
2YDM
,
8QHL
,
5AM9
,
4BZR
,
7Q29
,
7Q49
,
4BZS
,
2XY9
,
2XYD
,
7Q28
,
6ZPT
,
6ZPQ
,
5AMB
,
1UZE
,
1O86
,
6EN5
,
4C2R
,
5AM8
,
4C2P
,
7Z70
,
4CA5
,
7Q26
,
7Q24
,
4UFA
,
7Q4E
,
7Q4C
,
7Q25
,
6H5X
,
6F9U
,
7Z6Z
,
6F9R
,
6QS1
,
3NXQ
,
4BXK
,
4C2N
,
6TT1
,
4APH
,
1O8A
,
5AMC
,
4APJ
ZINC - Investigational
ACE_HUMAN
ZINC - Metabolites
ACE_HUMAN
HPA
ENSG00000159640-ACE
Pharos - Targets
P12821
Orphanet
ACE
ZINC - Predictions - Purchasable
ACE_HUMAN
HMDB Protein
HMDBP01710
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