Reactome | alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+

alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+

Stable Identifier

R-HSA-508369

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+

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Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methylacetoacetyl-CoA and NADH + H+ to form alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15342248	Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics Thomson, JA, Pelletier, LA, Abreo, MA, Vanderpool, D, Margosiak, S, Li, B, Meng, JJ, Aust, RM, Rejto, PA, Tempczyk-Russell, A, Showalter, RE, Kissinger, CR, Agree, CS, Villafranca, JE	J Mol Biol	2004
12696021	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene. Sass, JO, Duran, M, Sperl, W, Lehnert, W, Zschocke, J, Ensenauer, R, Ruiter, JP, Feenstra, M, Poll-The, BT, Ofman, R	Am J Hum Genet	2003