Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methylacetoacetyl-CoA and NADH + H+ to form alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).
Ofman, R, Ruiter, JP, Feenstra, M, Duran, M, Poll-The, BT, Zschocke, J, Ensenauer, R, Lehnert, W, Sass, JO, Sperl, W
Kissinger, CR, Rejto, PA, Pelletier, LA, Thomson, JA, Showalter, RE, Abreo, MA, Agree, CS, Margosiak, S, Meng, JJ, Aust, RM, Vanderpool, D, Li, B, Tempczyk-Russell, A, Villafranca, JE
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