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PTGES3 [nucleoplasm]
Stable Identifier
R-HSA-5082403
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Prostaglandin E synthase 3, cPGES
Icon
Locations in the PathwayBrowser for interactor UniProt:Q02790 FKBP4
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1 activation (Homo sapiens)
Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15185 PTGES3
Gene Names
PTGES3, P23, TEBP
Chain
chain:1-160
Reference Genes
BioGPS Gene:10728 PTGES3
COSMIC (genes):PTGES3 PTGES3
CTD Gene:10728 PTGES3
dbSNP Gene:10728 PTGES3
ENSEMBL:ENSG00000110958 PTGES3
ENSEMBL_homo_sapiens_GENE:ENSG00000110958.16 PTGES3
HGNC:16049 PTGES3
KEGG Gene (Homo sapiens):10728 PTGES3
Monarch:10728 PTGES3
NCBI Gene:10728 PTGES3
OMIM:607061 PTGES3
UCSC:Q15185 PTGES3
Reference Transcript
RefSeq:NM_006601.6 PTGES3
RefSeq:NM_001282601.1 PTGES3
RefSeq:NM_001282604.1 PTGES3
RefSeq:NM_001282602.1 PTGES3
RefSeq:NM_001282605.1 PTGES3
RefSeq:NM_001282603.1 PTGES3
Other Identifiers
10728
11743372_s_at
11747662_x_at
11751818_x_at
11753366_x_at
16766283
200627_PM_at
200627_at
2421920
2421921
2473546
2793347
3163060
32548_at
3458058
3458059
3458060
3458061
3458065
3458070
3458073
3458076
3458078
3458092
7964250
GE79257
GO:0000723
GO:0000781
GO:0001516
GO:0003720
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005697
GO:0005737
GO:0005829
GO:0005975
GO:0005978
GO:0006091
GO:0006457
GO:0006629
GO:0006631
GO:0006633
GO:0006693
GO:0007004
GO:0007165
GO:0016740
GO:0016853
GO:0019371
GO:0023052
GO:0032200
GO:0032991
GO:0042327
GO:0042921
GO:0043226
GO:0043588
GO:0048144
GO:0048856
GO:0050220
GO:0050821
GO:0051082
GO:0051085
GO:0051087
GO:0051131
GO:0051879
GO:0051973
GO:0060430
GO:0065003
GO:0070182
GO:0101031
GO:0140097
GO:1905323
HMNXSV003016817
HMNXSV003057078
ILMN_1719749
L24804_at
TC12001612.hg
TC12002910.hg
g12804292_3p_at
g12804292_3p_x_at
Participates
as an output of
Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)
Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)
HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Homo sapiens)
as a component of
2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)
AHR:2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C2:NR3C2 ligands [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:AR:Androgens [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm] (Homo sapiens)
HSF1:HSP90:PTGES3 [nucleoplasm] (Homo sapiens)
HSF1 trimer:HSP90:FKBP4:PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:FKBP4:PTGES3 [nucleoplasm] (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
ESR2:chaperone complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PTGES3 [cytosol]
Inferred To
ptges3a [nucleoplasm]
(Danio rerio)
Ghost homologue of PTGES3 [nucleoplasm]
(Canis familiaris)
wos2 [nucleoplasm]
(Schizosaccharomyces pombe)
PTGES3 [nucleoplasm]
(Bos taurus)
PTGES3 [nucleoplasm]
(Dictyostelium discoideum)
PTGES3 [nucleoplasm]
(Gallus gallus)
PTGES3 [nucleoplasm]
(Plasmodium falciparum)
PTGES3 [nucleoplasm]
(Sus scrofa)
Ptges3 [nucleoplasm]
(Mus musculus)
Ptges3 [nucleoplasm]
(Rattus norvegicus)
SBA1 [nucleoplasm]
(Saccharomyces cerevisiae)
daf-41 [nucleoplasm]
(Caenorhabditis elegans)
p23 [nucleoplasm]
(Drosophila melanogaster)
ptges3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001269533.1
,
NP_006592.3
,
NP_001269531.1
,
NP_001269534.1
,
NP_001269532.1
,
NP_001269530.1
Guide to Pharmacology - Targets
1379
OpenTargets
ENSG00000110958
GeneCards
Q15185
HPA
ENSG00000110958-PTGES3
Ensembl
ENST00000414274
,
ENSP00000262033
,
ENST00000436399
,
ENST00000262033
,
ENSP00000405299
,
ENST00000448157
,
ENSP00000414892
,
ENSG00000110958
,
ENSP00000402385
PRO
Q15185
Pharos - Targets
Q15185
HMDB Protein
HMDBP10674
PDB
1EJF
,
7L7I
,
7KRJ
,
7L7J
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.857
9
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.847
7
UniProt:P53041 PPP5C
2
PPP5C [cytosol]
(R-HSA-5675402)
PPP5C [nucleoplasm]
(R-HSA-5683410)
0.725
4
UniProt:O94763 RMP
0.669
3
UniProt:O14802 POLR3A
2
POLR3A [cytosol]
(R-HSA-1964433)
POLR3A [nucleoplasm]
(R-HSA-83700)
0.669
3
UniProt:Q9NRG4 SMYD2
1
SMYD2 [nucleoplasm]
(R-HSA-3222233)
0.669
3
UniProt:Q9Y463 DYR1B
0.643
3
UniProt:P04150 NR3C1
3
SUMO1-K277,K293-NR3C1 [nucleoplasm]
(R-HSA-4341106)
NR3C1 [cytosol]
(R-HSA-5618118)
NR3C1 [nucleoplasm]
(R-HSA-879837)
0.643
4
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.643
5
UniProt:Q14190 SIM2
0.573
2
UniProt:Q96GD4 AURKB
3
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [nucleoplasm]
(R-HSA-4655360)
AURKB [cytosol]
(R-HSA-174231)
0.527
2
UniProt:Q9HCK5 AGO4
1
EIF2C4 [cytosol]
(R-HSA-210612)
0.527
3
UniProt:Q7Z6J6 FRMD5
0.527
2
UniProt:Q12789 GTF3C1
1
GTF3C1 [nucleoplasm]
(R-HSA-83697)
0.527
3
UniProt:O95905 ECD
0.527
3
UniProt:Q9P2P1 NYNRI
0.527
2
UniProt:Q9UBB6 NCDN
0.527
2
UniProt:Q6P1M9 ARMX5
0.527
2
UniProt:Q8IV38 ANKY2
0.527
3
UniProt:Q96IC2 REXO5
0.527
2
UniProt:Q5THK1 PR14L
0.527
3
UniProt:O00522 KRIT1
0.527
2
UniProt:Q96EK5 KBP
0.527
3
UniProt:Q07864 POLE
1
POLE [nucleoplasm]
(R-HSA-68473)
0.527
3
UniProt:P51957 NEK4
0.527
2
UniProt:Q14318 FKBP8
2
PolyUb-FKBP8 [mitochondrial outer membrane]
(R-HSA-6783001)
FKBP8 [mitochondrial outer membrane]
(R-HSA-5696928)
0.527
3
UniProt:Q9GZT9 EGLN1
1
EGLN1 [cytosol]
(R-HSA-1234108)
0.527
3
UniProt:Q9NUG6 PDRG1
0.527
2
UniProt:Q9NWK9 BCD1
0.527
2
UniProt:Q9Y312 AAR2
0.527
2
UniProt:Q96JG8 MAGD4
0.527
2
UniProt:O95248 SBF1
2
SBF1 [cytosol]
(R-HSA-8876843)
SBF1 [endoplasmic reticulum membrane]
(R-HSA-6809747)
0.527
2
UniProt:O00170 AIP
2
AIP [cytosol]
(R-HSA-8936839)
AIP [nucleoplasm]
(R-HSA-8937156)
0.527
2
UniProt:Q9NZ71 RTEL1
2
RTEL1 [cytosol]
(R-HSA-2564769)
RTEL1 [nucleoplasm]
(R-HSA-5686112)
0.527
2
UniProt:Q9HBG6 IFT122
2
IFT122 [ciliary tip]
(R-HSA-5625346)
IFT122 [cilium]
(R-HSA-5610379)
0.527
3
UniProt:Q709F0 ACAD11
1
ACAD11 [mitochondrial inner membrane]
(R-HSA-5695987)
0.527
2
UniProt:P51530 DNA2
1
DNA2 [nucleoplasm]
(R-HSA-68465)
0.527
2
UniProt:Q02790 FKBP4
3
FKBP4 [nucleoplasm]
(R-HSA-8939162)
FKBP4 [nucleoplasm]
(R-HSA-5324621)
FKBP4 [cytosol]
(R-HSA-5618108)
0.527
2
UniProt:Q8TAT5 NEIL3
2
NEIL3 [nucleoplasm]
(R-HSA-9629184)
NEIL3 D132V [nucleoplasm]
(R-HSA-9629268)
0.527
3
UniProt:Q8NI77 KIF18A
1
KIF18A [cytosol]
(R-HSA-376239)
0.527
3
UniProt:O14654 IRS4
2
p-Y-IRS4 [plasma membrane]
(R-HSA-2424302)
IRS4 [plasma membrane]
(R-HSA-2424297)
0.499
2
UniProt:Q9UKV8 AGO2
2
AGO2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.499
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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