HSP70:DNAJB1 binds HSF1

Stable Identifier
R-HSA-5082384
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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During attenuation and recovery from heat shock, increased levels of HSP70 and HDJ1 (HSP40) were found to associate with the HSF1 activation domain, repressing its transcriptional activity (Shi Y et al. 1998)

Literature References
PubMed ID Title Journal Year
1628823 The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression

Abravaya, K, Myers, MP, Murphy, SP, Morimoto, RI

Genes Dev. 1992
1607379 Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor

Baler, R, Welch, WJ, Voellmy, R

J. Cell Biol. 1992
9499401 Molecular chaperones as HSF1-specific transcriptional repressors

Shi, Y, Mosser, DD, Morimoto, RI

Genes Dev. 1998
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