Reactome | HSF1-mediated gene expression

HSF1-mediated gene expression

Stable Identifier

R-HSA-5082356

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Combination of chromatin immunoprecipitation (ChIP) microarray analysis and time course gene expression microarray analysis with and without siRNA-mediated inhibition of HSF1 showed that human HSF1 can induce the expression of different sets of target genes to maintain a wide range of biological processes (e.g., anti-apoptosis, RNA splicing, ubiquitination)(Page TG et al. 2006; Vihervaara A. et al. 2013). However, HSF1 is best known for rapid stress-induced upregulation of certain genes related to protein folding, such as HSPA1A/HSP70, HSPC/HSP90, HSPB1/HSP27, and DNAJB1/HSP40 (Mosser DD et al. 1988; Trinklein ND et al. 2004a,b; Page TG et al. 2006; Vihervaara A. et al. 2013).

In the nucleus acetylation of Histone H3 is linked to the function of the Elongator complex in transcription (Kim JH et al. 2002). Elongator complex protein 3 (ELP3), a catalytic acetyltransferase subunit of the Elongator complex, has been reported to regulate the transcription of HSP70 gene, and the histone acetyltransferase (HAT) domain of ELP3 is essential for this function (Han Q et al. 2007; Li F et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
8455624	Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1 Voellmy, R, Baler, R, Dahl, G	Mol. Cell. Biol.	1993
15270074	Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation Chen, WC, Kingston, RE, Trinklein, ND, Myers, RM	Cell Stress Chaperones	2004
17216044	Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival Wolfinger, RD, Yang, L, Sikder, D, Thomas, RS, Kodadek, T, Page, TJ, Pluta, L	Mol Biosyst	2006