STAT5 dimers translocate to the nucleus

Stable Identifier
R-HSA-507937
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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STAT5 dimers translocate to the nucleus
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Interleukin-7 (IL7)-activated Signal transducer and activator of transcription 5A or 5B (typically referred to as STAT5) is recruited rapidly to the promoters of IL7-regulated genes (Ye et al. 2001, Stanton & Brodeur 2005).

Literature References
PubMed ID Title Journal Year
11728342 The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation

Honjo, T, Kurooka, H, Agata, Y, Ikuta, K, Kitamura, T, Lee, HC, Shimizu, A, Ye, SK

Immunity 2001
15749844 Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene

Stanton, ML, Brodeur, PH

J. Immunol. 2005
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Inferred From
Phosphorylated Stat5 Dimer Translocates to the Nucleus (Mus musculus)
Authored
Ray, KP  (2010-05-17)
Reviewed
Waters, MJ  (2011-06-23)
Dooms, H  (2011-03-17)
Villarino, A  (2011-02-11)
Created
Jupe, S  (2010-02-09)
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