STAT5 dimers translocate to the nucleus

Stable Identifier
R-HSA-507937
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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STAT5 dimers translocate to the nucleus
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Interleukin-7 (IL7)-activated Signal transducer and activator of transcription 5A or 5B (typically referred to as STAT5) is recruited rapidly to the promoters of IL7-regulated genes (Ye et al. 2001, Stanton & Brodeur 2005).

Literature References
PubMed ID Title Journal Year
15749844 Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene

Stanton, ML, Brodeur, PH

J. Immunol. 2005
11728342 The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation

Ye, SK, Agata, Y, Lee, HC, Kurooka, H, Kitamura, T, Shimizu, A, Honjo, T, Ikuta, K

Immunity 2001
Participants
Input
Output
Participant Of
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Authored
Ray, KP  (2010-05-17)
Reviewed
Villarino, A  (2011-02-11)
Dooms, H  (2011-03-17)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2010-02-09)