Aquaporins passively transport glycerol into cells

Stable Identifier
Reaction [transition]
Homo sapiens
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Aquaporin-3 (AQP3), AQP7, AQP9, and AQP10 are 6-pass transmembrane proteins that passively transport glycerol across the plasma membrane through a pore in each subunit of a homotetramer.

Literature References
PubMed ID Title Journal Year
10510269 Functional characterization and localization of AQP3 in the human colon

Silberstein, C, Kierbel, A, Amodeo, G, Zotta, E, Bigi, F, Berkowski, D, Ibarra, C

Braz J Med Biol Res 1999
9405233 Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability

Kuriyama, H, Kawamoto, S, Ishida, N, Ohno, I, Mita, S, Matsuzawa, Y, Matsubara, K, Okubo, K

Biochem Biophys Res Commun 1997
12084581 Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin

Ishibashi, K, Morinaga, T, Kuwahara, M, Sasaki, S, Imai, M

Biochim Biophys Acta 2002
16596446 Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line

Kida, H, Miyoshi, T, Manabe, K, Takahashi, N, Konno, T, Ueda, S, Chiba, T, Shimizu, T, Okada, Y, Morishima, S

J Membr Biol 2005
11573934 Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum

Hatakeyama, S, Yoshida, Y, Tani, T, Koyama, Y, Nihei, K, Ohshiro, K, Kamiie, JI, Yaoita, E, Suda, T, Hatakeyama, K, Yamamoto, T

Biochem Biophys Res Commun 2001
19590626 Altered aquaporin 9 expression and localization in human hepatocellular carcinoma

Padma, S, Smeltz, AM, Banks, PM, Iannitti, DA, McKillop, IH

HPB (Oxford) 2009
11952783 Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation

Kondo, H, Shimomura, I, Kishida, K, Kuriyama, H, Makino, Y, Nishizawa, H, Matsuda, M, Maeda, N, Nagaretani, H, Kihara, S, Kurachi, Y, Nakamura, T, Funahashi, T, Matsuzawa, Y

Eur J Biochem 2002
16325777 Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers

Marrades, MP, Milagro, FI, Martinez, JA, Moreno-Aliaga, MJ

Biochem Biophys Res Commun 2006
9369468 Mercury-sensitive residues and pore site in AQP3 water channel

Kuwahara, M, Gu, Y, Ishibashi, K, Marumo, F, Sasaki, S

Biochemistry 1997
18555844 Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue

Fain, JN, Buehrer, B, Bahouth, SW, Tichansky, DS, Madan, AK

Metabolism 2008
18678926 Compartmentalization of aquaporins in the human intestine

Cohly, HH, Isokpehi, R, Rajnarayanan, RV

Int J Environ Res Public Health 2008
18762715 Functional characterization of human aquaporin 9 as a facilitative glycerol carrier

Ohgusu, Y, Ohta, KY, Ishii, M, Katano, T, Urano, K, Watanabe, J, Inoue, K, Yuasa, H

Drug Metab Pharmacokinet 2008
11027599 Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain

Elkjaer, M, Vajda, Z, Nejsum, LN, Kwon, T, Jensen, UB, Amiry-Moghaddam, M, Fr√łkiaer, J, Nielsen, S

Biochem Biophys Res Commun 2000
10564231 Functional and molecular characterization of the human neutral solute channel aquaporin-9

Tsukaguchi, H, Weremowicz, S, Morton, CC, Hediger, MA

Am J Physiol 1999
Event Information
Catalyst Activity

glycerol channel activity of AQP3,7,9,10 [plasma membrane]

Orthologous Events
Cross References
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