Aquaporins passively transport water into cells

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R-HSA-507868
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Reaction [transition]
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Homo sapiens
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Aquaporin-0 (AQP0, also known as MIP), AQP1, AQP2, AQP3, AQP4, AQP5, AQP6, AQP7, AQP8, AQP9, AQP10 and AQP11 are 6-pass transmembrane proteins that passively transport water across the plasma membrane according to the concentration gradient. Each molecule contains a water channel and subunits assemble into homotetramers. In principle water can move in either direction through an aquaporin, however in vivo flow may occur in only one direction. Conductance of water by AQP0 and AQP11 are low relative to other aquaporins. AQP11 and AQP12 are not fully characterised and their ability to to allow transport of water is still debated .

Literature References
PubMed ID Title Journal Year
11231887 Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors

Fischer, H, Stenling, R, Rubio, C, Lindblom, A

BMC Physiol 2001
16596446 Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line

Kida, H, Miyoshi, T, Manabe, K, Takahashi, N, Konno, T, Ueda, S, Chiba, T, Shimizu, T, Okada, Y, Morishima, S

J Membr Biol 2005
19383790 Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

Ho, JD, Yeh, R, Sandstrom, A, Chorny, I, Harries, WE, Robbins, RA, Miercke, LJ, Stroud, RM

Proc Natl Acad Sci U S A 2009
8140421 Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine

Deen, PM, Verdijk, MA, Knoers, NV, Wieringa, B, Monnens, LA, van Os, CH, van Oost, BA

Science 1994
19857466 Intact AQP0 performs cell-to-cell adhesion

Kumari, SS, Varadaraj, K

Biochem Biophys Res Commun 2009
16325777 Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers

Marrades, MP, Milagro, FI, Martinez, JA, Moreno-Aliaga, MJ

Biochem Biophys Res Commun 2006
18555844 Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue

Fain, JN, Buehrer, B, Bahouth, SW, Tichansky, DS, Madan, AK

Metabolism 2008
11076974 The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers

Kamsteeg, EJ, Heijnen, I, van Os, CH, Deen, PM

J Cell Biol 2000
15948717 Purification and functional characterization of aquaporin-8

Liu, K, Nagase, H, Huang, CG, Calamita, G, Agre, P

Biol Cell 2006
23359558 In silico study of human aquaporin AQP11 and AQP12 channels

Calvanese, L, Pellegrini-Calace, M, Oliva, R

Protein Sci. 2013
18678926 Compartmentalization of aquaporins in the human intestine

Cohly, HH, Isokpehi, R, Rajnarayanan, RV

Int J Environ Res Public Health 2008
1510932 Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein

Zeidel, ML, Ambudkar, SV, Smith, BL, Agre, P

Biochemistry 1992
18511455 Novel variants in human Aquaporin-4 reduce cellular water permeability

Sorani, MD, Zador, Z, Hurowitz, E, Yan, D, Giacomini, KM, Manley, GT

Hum Mol Genet 2008
18948439 Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport

Larocca, MC, Soria, LR, Espelt, MV, Lehmann, GL, Marinelli, RA

Am J Physiol Gastrointest Liver Physiol 2009
19574955 Concerted action of two cation filters in the aquaporin water channel

Wu, B, Steinbronn, C, Alsterfjord, M, Zeuthen, T, Beitz, E

EMBO J 2009
15703994 Distribution of AQP2 and AQP3 water channels in human tissue microarrays

Mobasheri, A, Wray, S, Marples, D

J Mol Histol 2005
8621489 The human Aquaporin-5 gene. Molecular characterization and chromosomal localization

Lee, MD, Bhakta, KY, Raina, S, Yonescu, R, Griffin, CA, Copeland, NG, Gilbert, DJ, Jenkins, NA, Preston, GM, Agre, P

J Biol Chem 1996
16407156 Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons

Beitz, E, Wu, B, Holm, LM, Schultz, JE, Zeuthen, T

Proc Natl Acad Sci U S A 2006
19170255 Distribution of the AQP4 water channel in normal human tissues: protein and tissue microarrays reveal expression in several new anatomical locations, including the prostate gland and seminal vesicles

Mobasheri, A, Marples, D, Young, IS, Floyd, RV, Moskaluk, CA, Frigeri, A

Channels (Austin) 2007
7530250 Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues

Raina, S, Preston, GM, Guggino, WB, Agre, P

J Biol Chem 1995
21251984 Water permeability and characterization of aquaporin-11

Yakata, K, Tani, K, Fujiyoshi, Y

J. Struct. Biol. 2011
12801959 Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas

Burghardt, B, Elkaer, ML, Kwon, TH, Rácz, GZ, Varga, G, Steward, MC, Nielsen, S

Gut 2003
11952783 Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation

Kondo, H, Shimomura, I, Kishida, K, Kuriyama, H, Makino, Y, Nishizawa, H, Matsuda, M, Maeda, N, Nagaretani, H, Kihara, S, Kurachi, Y, Nakamura, T, Funahashi, T, Matsuzawa, Y

Eur J Biochem 2002
18202181 Mechanism of selectivity in aquaporins and aquaglyceroporins

Hub, JS, de Groot, BL

Proc Natl Acad Sci U S A 2008
18501347 Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract

Varadaraj, K, Kumari, SS, Patil, R, Wax, MB, Mathias, RT

Exp Eye Res 2008
17374283 Expression of aquaporin 8 in colonic epithelium with diarrhoea-predominant irritable bowel syndrome

Wang, JP, Hou, XH

Chin Med J (Engl) 2007
19144687 Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating

Moeller, HB, MacAulay, N, Knepper, MA, Fenton, RA

Am J Physiol Renal Physiol 2009
11532455 A refined structure of human aquaporin-1

de Groot, BL, Engel, A, Grubmüller, H

FEBS Lett 2001
9405233 Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability

Kuriyama, H, Kawamoto, S, Ishida, N, Ohno, I, Mita, S, Matsuzawa, Y, Matsubara, K, Okubo, K

Biochem Biophys Res Commun 1997
10564231 Functional and molecular characterization of the human neutral solute channel aquaporin-9

Tsukaguchi, H, Weremowicz, S, Morton, CC, Hediger, MA

Am J Physiol 1999
14514735 Aquaporin expression in normal human kidney and in renal disease

Bedford, JJ, Leader, JP, Walker, RJ

J Am Soc Nephrol 2003
14592814 Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology

Mobasheri, A, Marples, D

Am J Physiol Cell Physiol 2004
9829975 Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5

Meinild, AK, Klaerke, DA, Zeuthen, T

J Biol Chem 1998
18762715 Functional characterization of human aquaporin 9 as a facilitative glycerol carrier

Ohgusu, Y, Ohta, KY, Ishii, M, Katano, T, Urano, K, Watanabe, J, Inoue, K, Yuasa, H

Drug Metab Pharmacokinet 2008
8855281 The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain

Lu, M, Lee, MD, Smith, BL, Jung, JS, Agre, P, Verdijk, MA, Merkx, G, Rijss, JP, Deen, PM

Proc Natl Acad Sci U S A 1996
18768791 High-resolution x-ray structure of human aquaporin 5

Horsefield, R, Nordén, K, Fellert, M, Backmark, A, Törnroth-Horsefield, S, Terwisscha van Scheltinga, AC, Kvassman, J, Kjellbom, P, Johanson, U, Neutze, R

Proc Natl Acad Sci U S A 2008
7678419 CHIP28 water channels are localized in constitutively water-permeable segments of the nephron

Nielsen, S, Smith, BL, Christensen, EI, Knepper, MA, Agre, P

J Cell Biol 1993
19590626 Altered aquaporin 9 expression and localization in human hepatocellular carcinoma

Padma, S, Smeltz, AM, Banks, PM, Iannitti, DA, McKillop, IH

HPB (Oxford) 2009
7510718 Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct

Sasaki, S, Fushimi, K, Saito, H, Saito, F, Uchida, S, Ishibashi, K, Kuwahara, M, Ikeuchi, T, Inui, K, Nakajima, K

J Clin Invest 1994
14701836 Aquaporin-1, nothing but a water channel

Tsunoda, SP, Wiesner, B, Lorenz, D, Rosenthal, W, Pohl, P

J Biol Chem 2004
3049610 Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules

Denker, BM, Smith, BL, Kuhajda, FP, Agre, P

J Biol Chem 1988
20147624 Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity

Oliva, R, Calamita, G, Thornton, JM, Pellegrini-Calace, M

Proc Natl Acad Sci U S A 2010
1373524 Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein

Preston, GM, Carroll, TP, Guggino, WB, Agre, P

Science 1992
11034202 Structural determinants of water permeation through aquaporin-1

Murata, K, Mitsuoka, K, Hirai, T, Walz, T, Agre, P, Heymann, JB, Engel, A, Fujiyoshi, Y

Nature 2000
17178220 Identification of arylsulfonamides as Aquaporin 4 inhibitors

Huber, VJ, Tsujita, M, Yamazaki, M, Sakimura, K, Nakada, T

Bioorg Med Chem Lett 2007
11027599 Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain

Elkjaer, M, Vajda, Z, Nejsum, LN, Kwon, T, Jensen, UB, Amiry-Moghaddam, M, Frøkiaer, J, Nielsen, S

Biochem Biophys Res Commun 2000
9369468 Mercury-sensitive residues and pore site in AQP3 water channel

Kuwahara, M, Gu, Y, Ishibashi, K, Marumo, F, Sasaki, S

Biochemistry 1997
7535000 Water channel expression in human ADPKD kidneys

Bachinsky, DR, Sabolic, I, Emmanouel, DS, Jefferson, DM, Carone, FA, Brown, D, Perrone, RD

Am J Physiol 1995
9806845 Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene

Koyama, N, Ishibashi, K, Kuwahara, M, Inase, N, Ichioka, M, Sasaki, S, Marumo, F

Genomics 1998
11001937 Functional impairment of lens aquaporin in two families with dominantly inherited cataracts

Francis, P, Chung, JJ, Yasui, M, Berry, V, Moore, A, Wyatt, MK, Wistow, G, Bhattacharya, SS, Agre, P

Hum Mol Genet 2000
17920625 Human cataract lens membrane at subnanometer resolution

Buzhynskyy, N, Girmens, JF, Faigle, W, Scheuring, S

J Mol Biol 2007
11573934 Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum

Hatakeyama, S, Yoshida, Y, Tani, T, Koyama, Y, Nihei, K, Ohshiro, K, Kamiie, JI, Yaoita, E, Suda, T, Hatakeyama, K, Yamamoto, T

Biochem Biophys Res Commun 2001
10510269 Functional characterization and localization of AQP3 in the human colon

Silberstein, C, Kierbel, A, Amodeo, G, Zotta, E, Bigi, F, Berkowski, D, Ibarra, C

Braz J Med Biol Res 1999
12084581 Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin

Ishibashi, K, Morinaga, T, Kuwahara, M, Sasaki, S, Imai, M

Biochim Biophys Acta 2002
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water channel activity of AQP0,1,2,3,4,5,7,8,9,10,11,12A [plasma membrane]
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