Reactome | CHRNE [plasma membrane]

CHRNE

Stable Identifier

R-HSA-507845

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Acetylcholine receptor subunit epsilon, ACHE_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Activation of Nicotinic Acetylcholine Receptors (Homo sapiens)
        
        Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable acetylcholine nicotinic receptors (Homo sapiens)
        
        Activation of highly sodium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly sodium permeable acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
        
        Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable acetylcholine nicotinic receptors (Homo sapiens)
        
        Activation of highly sodium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly sodium permeable acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q04844 CHRNE

Gene Names

CHRNE, ACHRE

Chain

signal peptide:1-20, chain:21-493

Reference Genes

BioGPS Gene:1145 CHRNE

COSMIC (genes):CHRNE CHRNE

CTD Gene:1145 CHRNE

dbSNP Gene:1145 CHRNE

ENSEMBL:ENSG00000108556 CHRNE

HGNC:1966 CHRNE

KEGG Gene (Homo sapiens):hsa:1145 CHRNE

Monarch:1145 CHRNE

NCBI Gene:1145 CHRNE

OMIM:100725 CHRNE

UCSC:Q04844 CHRNE

Reference Transcript

RefSeq:NM_000080.3 CHRNE

Other Identifiers

0006620520

1145

11735601_at

16840131

207274_at

2DF9

3742353

3742354

3742355

3742356

3742357

3742358

3742360

3742361

3742362

3742365

3742367

3742368

3742369

3742370

3742371

39834_at

8011734

A_23_P304279

AAD24503

AF105999

CAA47030

CCDS11058

CH471108

CHRNE

CHRNE-201

EAW90395

EAW90396

ENSG00000108556

ENSP00000293780

ENST00000293780

EntrezGene:1145

g4557462_3p_at

g4557462_3p_x_at

GE80887

GO:0003674

GO:0004871

GO:0004888

GO:0005216

GO:0005230

GO:0005575

GO:0005623

GO:0005886

GO:0005887

GO:0005892

GO:0006810

GO:0006811

GO:0006936

GO:0007165

GO:0007267

GO:0007271

GO:0007274

GO:0008150

GO:0008324

GO:0015276

GO:0015464

GO:0016020

GO:0016021

GO:0022848

GO:0022857

GO:0030054

GO:0032991

GO:0034220

GO:0035094

GO:0042166

GO:0042391

GO:0043167

GO:0045202

GO:0045211

GO:0050877

GO:0055085

GO:0060078

GO:0060079

GO:0098655

HGNC:1966

ILMN_1703346

IPR002394

IPR006029

IPR006201

IPR006202

IPR018000

IPR036719

IPR036734

MIM:100725

MIM:605809

MIM:608931

MIM:616324

NM_000080

NP_000071

PF02931

PF02932

PH_hs_0015915

PR00252

PR00254

TC17001032.hg

uc002fzk.2

UPI0000125262

X66403

X66403_at

XM_017024115

XP_016879604

Participant Of

hasMember

Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane]

Inferred To

Homologues of CHRNE [plasma membrane] (Caenorhabditis elegans)

CHRNE [plasma membrane] (Bos taurus)

CHRNE [plasma membrane] (Caenorhabditis elegans)

CHRNE [plasma membrane] (Canis familiaris)

CHRNE [plasma membrane] (Danio rerio)

CHRNE [plasma membrane] (Drosophila melanogaster)

CHRNE [plasma membrane] (Mus musculus)

CHRNE [plasma membrane] (Rattus norvegicus)

CHRNE [plasma membrane] (Sus scrofa)

CHRNE [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000071.1

ZINC - World Drugs

ACHE_HUMAN

GeneCards

Q04844

ZINC - Substances

ACHE_HUMAN

ZINC target

Q04844

PRO

Q04844

ZINC - Predictions - Purchasable

ACHE_HUMAN

Orphanet

15451

PDB

2DF9