Reactome | CHRNE [plasma membrane]

CHRNE [plasma membrane]

Stable Identifier

R-HSA-507845

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Acetylcholine receptor subunit epsilon, ACHE_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable postsynaptic acetylcholine nicotinic receptors (Homo sapiens)
        
        Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
      - Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable postsynaptic acetylcholine nicotinic receptors (Homo sapiens)
        
        Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)
        
        O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        Highly sodium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor alpha3-beta4 [plasma membrane] (Homo sapiens)
        
        Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)
        
        CHRNE [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q04844 CHRNE

Gene Names

CHRNE, ACHRE

Chain

signal peptide:1-20, chain:21-493

Reference Genes

BioGPS Gene:1145 CHRNE

COSMIC (genes):CHRNE CHRNE

CTD Gene:1145 CHRNE

dbSNP Gene:1145 CHRNE

ENSEMBL:ENSG00000108556 CHRNE

HGNC:1966 CHRNE

KEGG Gene (Homo sapiens):1145 CHRNE

Monarch:1145 CHRNE

NCBI Gene:1145 CHRNE

OMIM:100725 CHRNE

UCSC:Q04844 CHRNE

Reference Transcript

RefSeq:NM_000080.3 CHRNE

Other Identifiers

0006620520

1145

11735601_at

16840131

207274_at

3742352

3742353

3742354

3742355

3742356

3742357

3742358

3742360

3742361

3742362

3742365

3742367

3742368

3742369

3742370

3742371

39834_at

8011734

A_23_P304279

GE80887

GO:0003674

GO:0004888

GO:0005216

GO:0005230

GO:0005575

GO:0005886

GO:0005887

GO:0005892

GO:0006810

GO:0006811

GO:0006936

GO:0007165

GO:0007267

GO:0007268

GO:0007271

GO:0008150

GO:0008324

GO:0015464

GO:0016020

GO:0016021

GO:0022848

GO:0022857

GO:0030054

GO:0030594

GO:0031594

GO:0032991

GO:0034220

GO:0042391

GO:0043005

GO:0045202

GO:0045211

GO:0050877

GO:0055085

GO:0060078

GO:0060079

GO:0098655

GO:1904315

HMNXSV003050423

ILMN_1703346

PH_hs_0015915

TC17001032.hg

X66403_at

g4557462_3p_at

g4557462_3p_x_at

Participates

as a member of

Delta, epsilon, gamma subunits of acetylcholine receptor [plasma membrane] (Homo sapiens)

Inferred To

Homologues of CHRNE [plasma membrane] (Caenorhabditis elegans)

lgc-21 [plasma membrane] (Caenorhabditis elegans)

Chrne [plasma membrane] (Mus musculus)

Chrne [plasma membrane] (Rattus norvegicus)

chrne [plasma membrane] (Danio rerio)

CHRNE [plasma membrane] (Canis familiaris)

CHRNE [plasma membrane] (Xenopus tropicalis)

lgc-27 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000071.1

ZINC - World Drugs

ACHE_HUMAN

Guide to Pharmacology - Targets

477

OpenTargets

ENSG00000108556

ZINC - Substances

ACHE_HUMAN

ZINC target

Q04844

PRO

Q04844

GlyGen

Q04844

PDB

2DF9

GeneCards

Q04844

HPA

ENSG00000108556-CHRNE

Ensembl

ENSG00000108556, ENST00000649488, ENSP00000497829

Pharos - Targets

Q04844

Orphanet

15451

ZINC - Predictions - Purchasable

ACHE_HUMAN

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