Reactome | CHRNA2 [plasma membrane]

CHRNA2 [plasma membrane]

Stable Identifier

R-HSA-507840

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuronal acetylcholine receptor subunit alpha-2, ACHA2_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA2 [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA2 [plasma membrane] (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
        
        acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
        
        CHRNA2 [plasma membrane] (Homo sapiens)
      - Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptors alpha2(3) beta3(2) [plasma membrane] (Homo sapiens)
        
        CHRNA2 [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Homo sapiens)
        
        0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptors alpha2(3) beta3(2) [plasma membrane] (Homo sapiens)
        
        CHRNA2 [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine receptors alpha2(3) beta3(2) [plasma membrane] (Homo sapiens)
        
        CHRNA2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15822 CHRNA2

Gene Names

CHRNA2

Chain

signal peptide:1-26, chain:27-529

Reference Genes

BioGPS Gene:1135 CHRNA2

COSMIC (genes):CHRNA2 CHRNA2

CTD Gene:1135 CHRNA2

dbSNP Gene:1135 CHRNA2

ENSEMBL:ENSG00000120903 CHRNA2

HGNC:1956 CHRNA2

KEGG:hsa:1135 CHRNA2

Monarch:1135 CHRNA2

NCBI Gene:1135 CHRNA2

OMIM:118502 CHRNA2

UCSC:Q15822 CHRNA2

Reference Transcript

Other Identifiers

1135

11733820_at

11733821_a_at

11750665_a_at

11751026_a_at

17075712

207868_PM_at

207868_at

3129023

3129025

3129027

3129028

3129029

3129030

3129031

3129032

3129033

3129034

3129035

3129036

3129038

3129039

3129040

3129041

3129042

3129043

3129044

3129045

3129046

3129047

3129048

3129049

3129050

32425_at

81225_at

8149918

A_23_P251443

GE479352

GO:0004888

GO:0005215

GO:0005216

GO:0005230

GO:0005654

GO:0005886

GO:0005892

GO:0006811

GO:0007154

GO:0007165

GO:0007271

GO:0015464

GO:0016020

GO:0022848

GO:0023052

GO:0032991

GO:0034220

GO:0035094

GO:0043005

GO:0045171

GO:0045202

GO:0045211

GO:0050997

GO:0051899

GO:0055085

GO:0060078

GO:0060079

GO:0060089

GO:0071316

GO:0071944

GO:0095500

GO:0098828

GO:0120111

GO:1901363

GO:1905144

HMNXSV003004877

ILMN_1698849

PH_hs_0003697

TC08001080.hg

U62431_at

g4502822_3p_at

Participates

as a member of

acetylcholine receptor subunits [plasma membrane] (Homo sapiens)

as a component of

Acetylcholine receptors alpha2(3) beta3(2) [plasma membrane] (Homo sapiens)

Inferred To

CHRNA2 [plasma membrane] (Bos taurus)

CHRNA2 [plasma membrane] (Canis familiaris)

CHRNA2 [plasma membrane] (Gallus gallus)

CHRNA2 [plasma membrane] (Sus scrofa)

acr-6 [plasma membrane] (Caenorhabditis elegans)

nAChRbeta2 [plasma membrane] (Drosophila melanogaster)

Chrna2 [plasma membrane] (Mus musculus)

Chrna2 [plasma membrane] (Rattus norvegicus)

chrna2a [plasma membrane] (Danio rerio)

Cross References

Guide to Pharmacology - Targets

463

ENSEMBL

ENST00000407991, ENSG00000120903, ENSP00000385026, ENST00000240132, ENSP00000240132

OpenTargets

ENSG00000120903

GeneCards

CHRNA2

HPA

ENSG00000120903-CHRNA2

PRO

Q15822

Pharos - Targets

Q15822

GlyGen

Q15822

Orphanet

CHRNA2

HMDB Protein

HMDBP10856

PDB

5FJV