Reactome | PXLP-K341-GPT2 transaminates PYR to form L-Ala

PXLP-K341-GPT2 transaminates PYR to form L-Ala

Stable Identifier

R-HSA-507749

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2]

ReviewStatus

5/5

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PXLP-K341-GPT2 transaminates PYR to form L-Ala

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Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of pyruvate and glutamate to form alanine and 2-oxoglutarate (alpha-ketoglutarate) (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19360321	Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma Hedberg, JJ, Lindblom, P, Andersson, HB, Berg, AL, Lindstrom, AK, Glinghammar, B, Cotgreave, I, Rafter, I	Int J Mol Med	2009
11863375	cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase Hansen, BC, Shuldiner, AR, Blaileanu, G, Yang, RZ, Gong, DW	Genomics	2002