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BCL2L1 [cytosol]
Stable Identifier
R-HSA-50771
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Apoptosis regulator Bcl-X, Bcl-2-like 1 protein
Locations in the PathwayBrowser for interactor UniProt:Q16611
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating tumorigenic genes (Homo sapiens)
NFE2L2 dependent BCL2L1 expression (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)
FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1-mediated effects on programmed cell death (Homo sapiens)
SARS-CoV-1 7a binds BCL2L1 (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
SARS-CoV-1 E binds BCL2L1 (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07817 BCL2L1
Gene Names
BCL2L1, BCL2L, BCLX
Chain
chain:1-233
Reference Genes
BioGPS Gene:598 BCL2L1
COSMIC (genes):BCL2L1 BCL2L1
CTD Gene:598 BCL2L1
dbSNP Gene:598 BCL2L1
ENSEMBL:ENSG00000171552 BCL2L1
ENSEMBL_homo_sapiens_GENE:ENSG00000171552.14 BCL2L1
HGNC:992 BCL2L1
KEGG Gene (Homo sapiens):598 BCL2L1
Monarch:598 BCL2L1
NCBI Gene:598 BCL2L1
OMIM:600039 BCL2L1
UCSC:Q07817 BCL2L1
Reference Transcript
RefSeq:NM_001322242.1 BCL2L1
RefSeq:NM_001322240.1 BCL2L1
RefSeq:NM_001317920.1 BCL2L1
RefSeq:NM_001317919.1 BCL2L1
RefSeq:XM_011528964.2 BCL2L1
RefSeq:NM_138578.2 BCL2L1
RefSeq:NM_001322239.1 BCL2L1
RefSeq:NM_001317921.1 BCL2L1
RefSeq:NM_001191.3 BCL2L1
RefSeq:XM_017027993.1 BCL2L1
Other Identifiers
11739957_a_at
11739958_x_at
11759514_at
1615_at
16918244
206665_PM_s_at
206665_s_at
212312_PM_at
212312_at
215037_PM_s_at
215037_s_at
231228_PM_at
231228_at
34742_at
3902490
3902491
3902492
3902493
3902522
3902523
3902524
3902525
3902526
3902527
3902528
3902529
3902530
3902531
3902532
598
65477_at
8065569
82590_at
A_23_P210886
A_24_P100130
GE60374
GE60550
GO:0000910
GO:0001541
GO:0001701
GO:0001836
GO:0005515
GO:0005634
GO:0005635
GO:0005737
GO:0005739
GO:0005741
GO:0005743
GO:0005759
GO:0005783
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006897
GO:0006914
GO:0006915
GO:0006950
GO:0007005
GO:0007281
GO:0007283
GO:0008584
GO:0008630
GO:0008637
GO:0009314
GO:0009566
GO:0009605
GO:0009615
GO:0010507
GO:0012501
GO:0016020
GO:0016192
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0030672
GO:0031410
GO:0031965
GO:0031966
GO:0032465
GO:0032946
GO:0034097
GO:0035234
GO:0040008
GO:0042802
GO:0042803
GO:0042981
GO:0043066
GO:0043226
GO:0043524
GO:0044565
GO:0045202
GO:0046898
GO:0046902
GO:0046982
GO:0048856
GO:0050673
GO:0051093
GO:0051402
GO:0051434
GO:0051607
GO:0051881
GO:0061024
GO:0070584
GO:0071230
GO:0071312
GO:0071480
GO:0071839
GO:0072659
GO:0090201
GO:0097048
GO:0097136
GO:0097192
GO:0097284
GO:0098542
GO:1900118
GO:1901029
GO:1902042
GO:1902230
GO:1902236
GO:1903077
GO:2000242
GO:2000669
GO:2000811
GO:2001233
GO:2001240
GO:2001243
HMNXSV003013398
HMNXSV003029432
Hs.143912.0.A1_3p_at
Hs.305890.1.S1_3p_at
Hs.305890.2.S1_3p_a_at
ILMN_1654118
ILMN_1742410
PH_hs_0015713
TC20000756.hg
TC20001531.hg
Z23115_at
g4502380_3p_a_at
Participates
as an output of
FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)
NFE2L2 dependent BCL2L1 expression (Homo sapiens)
as a component of
E:BCL2L1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
7a:BLC2L1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
as an input of
SARS-CoV-1 E binds BCL2L1 (Homo sapiens)
SARS-CoV-1 7a binds BCL2L1 (Homo sapiens)
Other forms of this molecule
BCL2L1 [mitochondrial outer membrane]
Cross References
RefSeq
NP_001309168.1
,
NP_612815.1
,
NP_001304849.1
,
XP_016883482.1
,
NP_001309169.1
,
XP_011527266.1
,
NP_001304850.1
,
NP_001182.1
,
NP_001304848.1
,
NP_001309171.1
Guide to Pharmacology - Targets
2845
OpenTargets
ENSG00000171552
ZINC - Substances
B2CL1_HUMAN
ZINC - Biogenic
B2CL1_HUMAN
ZINC target
Q07817
PRO
Q07817
PDB
2M03
,
2O2N
,
6UVC
,
3SP7
,
7XGF
,
2M04
,
3ZLN
,
3ZK6
,
7JGW
,
6UVH
,
6F46
,
7JGV
,
3FDM
,
3PL7
,
4BPK
,
4A1U
,
3SPF
,
6UVF
,
3WIZ
,
2YJ1
,
3ZLO
,
1BXL
,
6VWC
,
4PPI
,
3ZLR
,
8U27
,
5VAY
,
6O0K
,
4HNJ
,
6O0L
,
2YQ6
,
1R2D
,
1R2E
,
4A1W
,
2B48
,
4CIN
,
2P1L
,
6DCN
,
5AGX
,
5FMJ
,
2YQ7
,
6UVD
,
4QVE
,
6O0O
,
1R2G
,
6O0M
,
4Z9V
,
5AGW
,
1R2H
,
3CVA
,
3FDL
,
7LH7
,
1G5J
,
6UVG
,
4IEH
,
4QVX
,
1YSI
,
4QVF
,
6ST2
,
5VX3
,
5B1Z
,
6UVE
,
2LPC
,
4C5D
,
6YLI
,
5FMK
,
4TUH
,
1YSG
,
6O0P
,
6DCO
,
6BF2
,
2LP8
,
2ME8
,
6LHD
,
3R85
,
7XGG
,
1LXL
,
2O2M
,
7CA4
,
6RNU
,
2YXJ
,
4C52
,
6X7I
,
6HJL
,
1R2I
,
3IO8
,
3QKD
,
2MEJ
,
3INQ
,
2ME9
,
4AQ3
,
2O1Y
,
1YSN
,
6ZHC
,
1MAZ
,
2PON
,
4EHR
,
5C3G
,
6IJQ
ZINC - Investigational
B2CL1_HUMAN
ZINC - Metabolites
B2CL1_HUMAN
GeneCards
Q07817
HPA
ENSG00000171552-BCL2L1
Ensembl
ENSP00000395545
,
ENSP00000401173
,
ENST00000376055
,
ENSP00000389688
,
ENSP00000504237
,
ENSP00000365230
,
ENST00000456404
,
ENSP00000411252
,
ENSP00000504536
,
ENSG00000171552
,
ENSP00000302564
,
ENST00000307677
,
ENSP00000390760
,
ENST00000676942
,
ENST00000677194
,
ENST00000434194
,
ENST00000422920
,
ENSP00000365223
,
ENST00000420488
,
ENST00000676582
,
ENST00000439267
,
ENSP00000503725
,
ENST00000376062
,
ENSP00000504387
,
ENST00000678563
Pharos - Targets
Q07817
ZINC - Predictions - Purchasable
B2CL1_HUMAN
Orphanet
25595
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92934 BAD
4
p-S99-BAD [cytosol]
(R-HSA-198335)
BAD [cytosol]
(R-HSA-50662)
BAD [mitochondrial outer membrane]
(R-HSA-114242)
p-S91-BAD [cytosol]
(R-HSA-217297)
0.976
48
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.955
37
UniProt:Q13323 BIK
0.914
12
UniProt:Q96LC9 BMF
3
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
BMF [plasma membrane]
(R-HSA-140209)
p-BMF(1-89) [cytosol]
(R-HSA-140529)
0.805
12
UniProt:O43521 BCL2L11
7
BCL2L11 [mitochondrial outer membrane]
(R-HSA-2976674)
BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]
(R-HSA-6802276)
BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]
(R-HSA-6802519)
p-S69-BCL2L11 [cytosol]
(R-HSA-2976671)
p-BCL2L11 [mitochondrial outer membrane]
(R-HSA-3145027)
p-BCL2L11 [cytosol]
(R-HSA-140525)
BCL2L11 [cytosol]
(R-HSA-2976673)
0.775
8
UniProt:Q9C000 NLRP1
1
NLRP1 [cytosol]
(R-HSA-561196)
0.646
9
UniProt:P55957 BID
4
MYS-BID(62-195) [mitochondrial outer membrane]
(R-HSA-114266)
MYS-BID(62-195) [cytosol]
(R-HSA-141373)
BID(1-195) [cytosol]
(R-HSA-50825)
BID(62-195) [cytosol]
(R-HSA-139953)
0.571
2
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:P0C671 BNIP5
0.556
3
UniProt:P56557 TM50B
0.556
3
UniProt:P22749 GNLY
2
GNLY [phagocytic vesicle lumen]
(R-HSA-6807564)
GNLY [extracellular region]
(R-HSA-6806691)
0.556
3
UniProt:Q8NBJ4 GOLM1
2
p-GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956938)
GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956710)
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q8IYJ2-2 C10ORF67
0.556
3
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:Q5T7V8 GORAB
0.556
3
UniProt:P27469 G0S2
1
G0S2 [lipid droplet]
(R-HSA-1989741)
0.556
3
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:Q6NTF9-3 Q6NTF93
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:Q7Z5B4-5 RIC3
0.556
3
UniProt:P49810 PSEN2
2
PSEN2(1-297) [plasma membrane]
(R-HSA-201599)
PSEN2(298-448) [plasma membrane]
(R-HSA-9013329)
0.543
3
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.524
2
UniProt:P45983 MAPK8
3
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.516
2
UniProt:Q07812 BAX
3
BAX [cytosol]
(R-HSA-139916)
BAX activated [cytosol]
(R-HSA-139907)
BAX [mitochondrial outer membrane]
(R-HSA-139949)
0.483
3
UniProt:Q9H2V7 SPNS1
0.463
3
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