Reactome | ATP5E [mitochondrial matrix]

ATP5E [mitochondrial matrix]

Stable Identifier

R-HSA-50508

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

ATP synthase epsilon chain, mitochondrial (EC 3.6.3.14)

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Formation of ATP by chemiosmotic coupling (Homo sapiens)
      - ADP and Pi bind to ATPase (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
      - ATPase synthesizes ATP (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
      - Enzyme-bound ATP is released (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Cristae formation (Homo sapiens)
    - F1Fo ATP synthase dimerizes (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
      - F1Fo ATP synthase dimer [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P56381 ATP5F1E

Gene Names

ATP5F1E, ATP5E

Chain

chain:1-51

Reference Genes

BioGPS Gene:514 ATP5F1E

COSMIC (genes):ATP5F1E ATP5F1E

CTD Gene:514 ATP5F1E

dbSNP Gene:514 ATP5F1E

ENSEMBL:ENSG00000124172 ATP5E

HGNC:838 ATP5F1E

KEGG Gene (Homo sapiens):514 ATP5F1E

Monarch:514 ATP5F1E

NCBI Gene:514 ATP5F1E

OMIM:606153 ATP5F1E

UCSC:P56381 ATP5F1E

Reference Transcript

RefSeq:NM_006886.3 ATP5F1E

Other Identifiers

0004760707

11754025_x_at

16920774

217801_at

230535_s_at

3483119

3483120

3911791

3911792

3911794

3911796

3911797

3911798

3911799

3911800

3911801

3911810

3911811

49157_at

514

65728_at

8067288

A_23_P252322

A_32_P92212

A_33_P3279765

GE558798

GE84383

GO:0000275

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005743

GO:0005753

GO:0005759

GO:0006091

GO:0006754

GO:0006810

GO:0006811

GO:0007005

GO:0008150

GO:0009058

GO:0015986

GO:0016020

GO:0016787

GO:0016874

GO:0022857

GO:0032991

GO:0034641

GO:0042407

GO:0042776

GO:0043226

GO:0044281

GO:0045261

GO:0046933

GO:0055085

GO:0061024

HMNXSV003031413

HMNXSV003052366

Hs.303023.0.A1_3p_at

ILMN_1756674

ILMN_3261197

PH_hs_0029333

PH_hs_0037642

TC20000993.hg

TC20001753.hg

g5901895_3p_at

Participates

as a component of

ATPase CF(1) [mitochondrial matrix] (Homo sapiens)

Inferred To

atp5f1e [mitochondrial matrix] (Danio rerio)

ATP5F1E [mitochondrial matrix] (Bos taurus)

ATP5F1E [mitochondrial matrix] (Canis familiaris)

ATP5F1E [mitochondrial matrix] (Sus scrofa)

ATP5E [mitochondrial matrix] (Gallus gallus)

ATP5E [mitochondrial matrix] (Rattus norvegicus)

ATP15 [mitochondrial matrix] (Saccharomyces cerevisiae)

sun [mitochondrial matrix] (Drosophila melanogaster)

atp15 [mitochondrial matrix] (Schizosaccharomyces pombe)

hpo-18 [mitochondrial matrix] (Caenorhabditis elegans)

Atp5f1e [mitochondrial matrix] (Mus musculus)

Cross References

RefSeq

NP_008817.1

Guide to Pharmacology - Targets

800

OpenTargets

ENSG00000124172

GeneCards

P56381

HPA

ENSG00000124172-ATP5F1E

Ensembl

ENST00000395663, ENST00000243997, ENSP00000379019, ENSP00000243997, ENSG00000124172, ENSP00000379023, ENST00000395659

PRO

P56381

Pharos - Targets

P56381

GlyGen

P56381

Orphanet

20155

HMDB Protein

HMDBP01206