Reactome | ATP5E [mitochondrial matrix]

ATP5E

Stable Identifier

R-HSA-50508

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

ATP synthase epsilon chain, mitochondrial (EC 3.6.3.14)

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Formation of ATP by chemiosmotic coupling (Homo sapiens)
      - ADP and Pi bind to ATPase (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
      - ATPase synthesizes ATP (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
      - Enzyme-bound ATP is released (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Cristae formation (Homo sapiens)
    - F1Fo ATP synthase dimerizes (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)
      - F1Fo ATP synthase dimer [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5E [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P56381 ATP5E

Gene Names

ATP5E

Chain

chain:1-51

Reference Genes

BioGPS Gene:514 ATP5E

COSMIC (genes):ATP5E ATP5E

CTD Gene:514 ATP5E

dbSNP Gene:514 ATP5E

ENSEMBL:ENSG00000124172 ATP5E

HGNC:838 ATP5E

KEGG Gene (Homo sapiens):ATP5F1E ATP5E

KEGG Gene (Homo sapiens):hsa:514 ATP5E

Monarch:514 ATP5E

NCBI Gene:514 ATP5E

OMIM:606153 ATP5E

UCSC:P56381 ATP5E

Reference Transcript

RefSeq:NM_006886.3 ATP5E

Other Identifiers

0004760707

11754025_x_at

217801_at

230535_s_at

3483119

3483120

3911794

3911796

3911797

3911798

3911799

3911800

3911801

3911810

3911811

49157_at

514

65728_at

8067288

A_23_P252322

A_32_P92212

A_33_P3279765

ATP5E

ATP5E-201

ATP5E-202

ATP5E-203

CCDS13476

ENSG00000124172

ENSP00000243997

ENSP00000379019

ENSP00000379023

ENST00000243997

ENST00000395659

ENST00000395663

EntrezGene:514

g5901895_3p_at

GE558798

GO:0000275

GO:0005739

GO:0005743

GO:0005753

GO:0005759

GO:0006754

GO:0006810

GO:0006811

GO:0015986

GO:0015992

GO:0016020

GO:0016787

GO:0016887

GO:0022857

GO:0042407

GO:0042776

GO:0045261

GO:0046933

GO:0099132

HGNC:838

Hs.303023.0.A1_3p_at

ILMN_1756674

ILMN_3261197

MIM:606153

MIM:614053

NM_006886

NP_008817

PF04627

PH_hs_0029333

PH_hs_0037642

TC20001753.hg

uc002yal.4

uc061yee.1

uc061yef.1

UPI000013CB4F

Participant Of

hasComponent

ATPase CF(1) [mitochondrial matrix]

Inferred To

Homologues of ATP5E [mitochondrial matrix] (Rattus norvegicus)

Homologues of ATP5E [mitochondrial matrix] (Taeniopygia guttata)

ATP5E [mitochondrial matrix] (Bos taurus)

ATP5E [mitochondrial matrix] (Danio rerio)

ATP5E [mitochondrial matrix] (Mus musculus)

ATP5E [mitochondrial matrix] (Rattus norvegicus)

ATP5E [mitochondrial matrix] (Sus scrofa)

ATP5E [mitochondrial matrix] (Taeniopygia guttata)

Ghost homologue of ATP5E [mitochondrial matrix] (Canis familiaris)

Ghost homologue of ATP5E [mitochondrial matrix] (Drosophila melanogaster)

Ghost homologue of ATP5E [mitochondrial matrix] (Gallus gallus)

Ghost homologue of ATP5E [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_008817.1

GeneCards

P56381

PRO

P56381

Orphanet

20155

HMDB Protein

HMDBP01206