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SAG [cytosol]
Stable Identifier
R-HSA-50320
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
S-arrestin, Retinal S-antigen, 48 kDa protein, Rod photoreceptor arrestin
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The phototransduction cascade (Homo sapiens)
Activation of the phototransduction cascade (Homo sapiens)
MII catalyses GDP/GTP exchange on Gt (Homo sapiens)
p-MII:SAG [photoreceptor disc membrane] (Homo sapiens)
SAG [cytosol] (Homo sapiens)
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
GRK1,4,7 phosphorylate MII to p-MII (Homo sapiens)
p-MII:SAG [photoreceptor disc membrane] (Homo sapiens)
SAG [cytosol] (Homo sapiens)
PP2A dephosphorylates p-RHO to RHO (Homo sapiens)
p-MII:SAG [photoreceptor disc membrane] (Homo sapiens)
SAG [cytosol] (Homo sapiens)
SAG binds p-MII to form p-MII:SAG (Homo sapiens)
SAG [cytosol] (Homo sapiens)
p-MII:SAG [photoreceptor disc membrane] (Homo sapiens)
SAG [cytosol] (Homo sapiens)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Homo sapiens)
p-MII:SAG [photoreceptor disc membrane] (Homo sapiens)
SAG [cytosol] (Homo sapiens)
p-RHO:SAG [photoreceptor disc membrane] (Homo sapiens)
SAG [cytosol] (Homo sapiens)
p-MII:SAG dissociates to p-RHO and SAG (Homo sapiens)
SAG [cytosol] (Homo sapiens)
p-RHO:SAG [photoreceptor disc membrane] (Homo sapiens)
SAG [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10523 SAG
Gene Names
SAG
Chain
chain:1-405
Reference Genes
BioGPS Gene:6295 SAG
COSMIC (genes):SAG SAG
CTD Gene:6295 SAG
dbSNP Gene:6295 SAG
ENSEMBL:ENSG00000130561 SAG
HGNC:10521 SAG
KEGG:hsa:6295 SAG
Monarch:6295 SAG
NCBI Gene:6295 SAG
OMIM:181031 SAG
UCSC:P10523 SAG
Reference Transcript
RefSeq:NM_000541.4 SAG
Other Identifiers
11722511_a_at
16892525
206671_PM_at
206671_at
2532853
2532856
2532857
2532858
2532859
2532860
2532861
2532863
2532865
2532867
2532868
2532869
2532870
2532871
2532872
2532873
2532874
2532875
2532876
2532877
2532878
2532881
2532882
2532885
2532886
2532887
2532888
2532889
2532890
2532891
31759_at
35660_at
35661_g_at
6295
8049301
A_23_P5853
A_33_P3232203
GO:0001664
GO:0001750
GO:0001917
GO:0002031
GO:0002046
GO:0004864
GO:0005515
GO:0005829
GO:0007165
GO:0007166
GO:0016020
GO:0016056
GO:0016192
GO:0042995
GO:0051219
GO:0098772
HMNXSV003044146
HMNXSV003049942
ILMN_1758619
PH_hs_0027111
TC02001418.hg
TC02003894.hg
X12453_at
g10880124_3p_at
Participates
as an input of
SAG binds p-MII to form p-MII:SAG (Homo sapiens)
as a component of
p-MII:SAG [photoreceptor disc membrane] (Homo sapiens)
p-RHO:SAG [photoreceptor disc membrane] (Homo sapiens)
as an output of
p-MII:SAG dissociates to p-RHO and SAG (Homo sapiens)
Inferred To
arr-1 [cytosol]
(Caenorhabditis elegans)
saga [cytosol]
(Danio rerio)
Sag [cytosol]
(Bos taurus)
Sag [cytosol]
(Mus musculus)
Sag [cytosol]
(Rattus norvegicus)
SAG [cytosol]
(Canis familiaris)
SAG [cytosol]
(Gallus gallus)
SAG [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000386444
,
ENST00000631149
,
ENST00000409110
,
ENSP00000486571
OpenTargets
ENSG00000130561
HPA
ENSG00000130561-SAG
PRO
P10523
Pharos - Targets
P10523
Orphanet
SAG
HMDB Protein
HMDBP02668
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49761 CLK3
0.556
3
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.527
4
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