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GRIK3 homomer binds glutamate
Stable Identifier
R-HSA-500708
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of kainate receptors upon glutamate binding (Homo sapiens)
Presynaptic function of Kainate receptors (Homo sapiens)
GRIK3 homomer binds glutamate (Homo sapiens)
General
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Kainate receptors bind glutamate in the ligand binding domain in the extracellular, N terminal region.
Literature References
PubMed ID
Title
Journal
Year
19342380
Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis
Gill, MB
,
Swanson, GT
,
Vivithanaporn, P
J Biol Chem
2009
Participants
Input
GRIK 3 homomer [plasma membrane]
(Homo sapiens)
L-Glu [extracellular region]
Output
GRIK3 homomer glutamate complex [plasma membrane]
(Homo sapiens)
Participates
as an event of
Presynaptic function of Kainate receptors (Homo sapiens)
Orthologous Events
GRIK3 homomer binds glutamate (Bos taurus)
GRIK3 homomer binds glutamate (Canis familiaris)
GRIK3 homomer binds glutamate (Drosophila melanogaster)
GRIK3 homomer binds glutamate (Gallus gallus)
GRIK3 homomer binds glutamate (Mus musculus)
GRIK3 homomer binds glutamate (Rattus norvegicus)
GRIK3 homomer binds glutamate (Sus scrofa)
GRIK3 homomer binds glutamate (Xenopus tropicalis)
Authored
Mahajan, SS (2010-01-05)
Reviewed
Tukey, D (2009-11-18)
Created
Mahajan, SS (2010-02-05)
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