Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2

Stable Identifier
Reaction [transition]
Homo sapiens
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Human pancreatic beta cells express glucose transporters 1 and (GLUT1, GLUT2), which are responsible for uptake of glucose from the extracellular medium into the cytosol. (Rodent pancreatic beta cells express only Glut2.)

Literature References
PubMed ID Title Journal Year
8987985 Structure-function analysis of liver-type (GLUT2) and brain-type (GLUT3) glucose transporters: expression of chimeric transporters in Xenopus oocytes suggests an important role for putative transmembrane helix 7 in determining substrate selectivity

Arbuckle, MI, Kane, S, Porter, LM, Seatter, MJ, Gould, GW

Biochemistry 1996
8027028 A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity

Mueckler, M, Kruse, M, Strube, M, Riggs, AC, Chiu, KC, Permutt, MA

J Biol Chem 1994
7929812 Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization

Morita, H, Yano, Y, Niswender, KD, May, JM, Whitesell, RR, Wu, L, Printz, RL, Granner, DK, Magnuson, MA, Powers, AC

J Clin Invest 1994
17380317 Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development

Richardson, CC, Hussain, K, Jones, PM, Persaud, S, Löbner, K, Boehm, A, Clark, A, Christie, MR

Diabetologia 2007
7593639 Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression

De Vos, A, Heimberg, H, Quartier, E, Huypens, P, Bouwens, L, Pipeleers, D, Schuit, F

J Clin Invest 1995
9751501 Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity

Wu, L, Fritz, JD, Powers, AC

Endocrinology 1998
11780755 GLUT2 in pancreatic and extra-pancreatic gluco-detection (review)

Thorens, B

Mol Membr Biol 2001
8457197 Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors

Colville, CA, Seatter, MJ, Jess, TJ, Gould, GW, Thomas, HM

Biochem J 1993
7589840 Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM

Ferrer, J, Benito, C, Gomis, R

Diabetes 1995
Catalyst Activity

glucose transmembrane transporter activity of GLUT1,2 [plasma membrane]

Orthologous Events
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