Reactome | Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2

Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2

Stable Identifier

R-HSA-499981

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2

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Human pancreatic beta cells express glucose transporters 1 and (GLUT1, GLUT2), which are responsible for uptake of glucose from the extracellular medium into the cytosol. (Rodent pancreatic beta cells express only Glut2.)

Literature References

PubMed ID	Title	Journal	Year
8027028	A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity Mueckler, M, Kruse, M, Strube, M, Riggs, AC, Chiu, KC, Permutt, MA	J Biol Chem	1994
8987985	Structure-function analysis of liver-type (GLUT2) and brain-type (GLUT3) glucose transporters: expression of chimeric transporters in Xenopus oocytes suggests an important role for putative transmembrane helix 7 in determining substrate selectivity Arbuckle, MI, Kane, S, Porter, LM, Seatter, MJ, Gould, GW	Biochemistry	1996
7929812	Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization Morita, H, Yano, Y, Niswender, KD, May, JM, Whitesell, RR, Wu, L, Printz, RL, Granner, DK, Magnuson, MA, Powers, AC	J Clin Invest	1994
17380317	Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development Richardson, CC, Hussain, K, Jones, PM, Persaud, S, Löbner, K, Boehm, A, Clark, A, Christie, MR	Diabetologia	2007
7593639	Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression De Vos, A, Heimberg, H, Quartier, E, Huypens, P, Bouwens, L, Pipeleers, D, Schuit, F	J Clin Invest	1995
9751501	Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity Wu, L, Fritz, JD, Powers, AC	Endocrinology	1998
11780755	GLUT2 in pancreatic and extra-pancreatic gluco-detection (review) Thorens, B	Mol Membr Biol	2001
8457197	Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors Colville, CA, Seatter, MJ, Jess, TJ, Gould, GW, Thomas, HM	Biochem J	1993
7589840	Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM Ferrer, J, Benito, C, Gomis, R	Diabetes	1995