Reactome | NT5C2 [cytosol]

NT5C2 [cytosol]

Stable Identifier

R-HSA-49189

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

5'-nucleotidase cytosolic II, cytosolic purine 5'-nucleotidase, high Km 5'-nucleotidase, Cytosolic purine 5'-nucleotidase

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
2848805	High Km soluble 5'-nucleotidase from human placenta Spychala, J, Fox, IH, Madrid-Marina, V	J Biol Chem	1988

External Reference Information

External Reference

UniProt:P49902 NT5C2

Gene Names

NT5C2, NT5B, NT5CP, PNT5

Chain

chain:1-561

Reference Genes

BioGPS Gene:22978 NT5C2

COSMIC (genes):NT5C2 NT5C2

CTD Gene:22978 NT5C2

dbSNP Gene:22978 NT5C2

ENSEMBL:ENSG00000076685 NT5C2

ENSEMBL:ENSG00000076685.19 NT5C2

HGNC:8022 NT5C2

KEGG Gene (Homo sapiens):22978 NT5C2

Monarch:22978 NT5C2

NCBI Gene:22978 NT5C2

OMIM:600417 NT5C2

UCSC:P49902 NT5C2

Reference Transcript

Other Identifiers

11722566_a_at

11722567_at

11722568_at

11754974_x_at

16717986

16718019

209155_PM_s_at

209155_s_at

22978

236703_PM_at

236703_at

31794_at

3304625

3304626

3304627

3304628

3304629

3304630

3304631

3304632

3304634

3304636

3304638

3304639

3304643

3304644

3304647

3304648

3304651

3304652

3304657

3304658

3304672

3304684

3304685

3304689

3304690

3304699

3304714

3304715

48978_at

738_at

7936064

A_23_P97906

A_33_P3255354

D38524_at

GE548927

GE79106

GO:0000166

GO:0000255

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006204

GO:0008152

GO:0008253

GO:0009117

GO:0016740

GO:0016787

GO:0036211

GO:0042802

GO:0046037

GO:0046040

GO:0046054

GO:0046085

GO:0046872

GO:0050146

GO:0050483

GO:0050484

GO:0050689

GO:0055086

GO:0061630

GO:0070936

GO:0098542

GO:0106411

GO:0140096

GO:1901135

HMNXSV003021743

HMNXSV003057309

Hs.97439.0.A1_3p_at

ILMN_1682165

PH_hs_0025034

TC10001626.hg

TC10002812.hg

g12804388_3p_a_at

Participates

as a component of

NT5C2 tetramer [cytosol] (Homo sapiens)

Inferred To

NT5C2 [cytosol] (Bos taurus)

NT5C2 [cytosol] (Caenorhabditis elegans)

NT5C2 [cytosol] (Canis familiaris)

NT5C2 [cytosol] (Danio rerio)

NT5C2 [cytosol] (Dictyostelium discoideum)

NT5C2 [cytosol] (Gallus gallus)

NT5C2 [cytosol] (Mus musculus)

NT5C2 [cytosol] (Rattus norvegicus)

NT5C2 [cytosol] (Sus scrofa)

nt5c2 [cytosol] (Xenopus tropicalis)

Nt5b [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_005269693.1, NP_036361.1, XP_005269696.1, NP_001127845.1

Guide to Pharmacology - Targets

1236

OpenTargets

ENSG00000076685

IntEnz

2.7.1.77

HPA

ENSG00000076685-NT5C2

GeneCards

P49902

Ensembl

ENST00000675326, ENST00000675985, ENST00000676449, ENSP00000502205, ENST00000676428, ENSP00000501689, ENSP00000502679, ENST00000674696, ENSP00000502215, ENST00000404739, ENSP00000339479, ENST00000343289, ENSP00000383960, ENSP00000502801, ENSG00000076685

PRO

P49902

Pharos - Targets

P49902

Orphanet

22735

HMDB Protein

HMDBP03750

PDB

5OPK, 6DDX, 2XJF, 5CQZ, 6DDC, 2XJE, 4H4B, 5CR7, 6FIR, 6DE0, 5OPL, 6DDY, 2XJD, 6FIS, 5OPM, 2JCM, 6DE1, 5OPN, 6DDH, 6DDZ, 2XJC, 6FIU, 6DDK, 5OPO, 5L50, 6DE2, 2XJB, 5L4Z, 6FIW, 6DDL, 5OPP, 6DE3, 2XCX, 6FXH, 6DD3, 2XCW, 2JC9, 6DDO, 5K7Y, 2XCV, 6DDQ, 2J2C, 6DDB

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	3