CTNNB1 T41 mutants aren't phosphorylated by GSK3beta

Stable Identifier
R-HSA-4839638
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CTNNB1 T41 mutants aren't phosphorylated by GSK3beta
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T41 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear accumulation of the protein (Moreno-Bueno et al, 2002; Taniguchi et al, 2002; reviewed in Polakis, 2012). T41 mutations have been identified in cancers of the liver and brain, as well as in the pituitary, endometrium, large intestine and skin, among others (reviewed in Polakis, 2000; Saito-Diaz et al, 2013).
Literature References
PubMed ID Title Journal Year
22438566 Wnt signaling in cancer

Polakis, P

Cold Spring Harb Perspect Biol 2012
10921899 Wnt signaling and cancer

Polakis, P

Genes Dev. 2000
23256519 The way Wnt works: Components and mechanism

Wang, X, Wallace, HA, Page-McCaw, A, Lee, E, Thorne, CA, Chen, TW, Saito-Diaz, K

Growth Factors 2013
12101426 Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

Roche, PC, Ross, JA, Taniguchi, K, Aderca, IN, Smith, DI, Roberts, LR, Qian, C, Nagorney, DM, Burgart, LJ, Liu, W, Dong, X, Murphy, LM

Oncogene 2002
12439748 Abnormalities of the APC/beta-catenin pathway in endometrial cancer

García-Rostán, G, Sarrio, D, Hardisson, D, Moreno-Bueno, G, Herman, JG, Sánchez, C, Guo, M, Prat, J, Cassia, R, Matías-Guiu, X, Palacios, J, Esteller, M

Oncogene 2002
Participants
Input
Participates
as an event of
Normal reaction
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
Functional status

Loss of function of pS45-CTNNB1 T41 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2013-10-30)
Reviewed
Salahshor, S  (2014-05-12)
Woodgett, J  (2014-05-22)
Created
Rothfels, K  (2013-11-01)
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