CTNNB1 S33 mutants aren't phosphorylated by GSK3beta

Stable Identifier
R-HSA-4839634
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CTNNB1 S33 mutants aren't phosphorylated by GSK3beta
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
S33 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear localization of the protein and enhanced WNT signaling (Groen et al, 2008; Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis, 2000). S33 mutations have been identified in cancers of the central nervous system, liver, endometrium and stomach, among others (reviewed in Polakis, 2000).
Literature References
PubMed ID Title Journal Year
10487827 Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation

Nhieu, JT, Renard, CA, Wei, Y, Cherqui, D, Zafrani, ES, Buendia, MA

Am. J. Pathol. 1999
10921899 Wnt signaling and cancer

Polakis, P

Genes Dev. 2000
18757411 Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies

Groen, RW, Oud, ME, Schilder-Tol, EJ, Overdijk, MB, ten Berge, D, Nusse, R, Spaargaren, M, Pals, ST

Cancer Res. 2008
12067995 beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer

Clements, WM, Wang, J, Sarnaik, A, Kim, OJ, MacDonald, J, Fenoglio-Preiser, C, Groden, J, Lowy, AM

Cancer Res. 2002
Participants
Input
Participates
as an event of
Normal reaction
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
Functional status

Loss of function of pS37,T41,S45-CTNNB1 S33 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2013-10-30)
Reviewed
Salahshor, S  (2014-05-12)
Woodgett, J  (2014-05-22)
Created
Rothfels, K  (2013-11-01)
Cite Us!