p-S54,92,203-BRF1 binds 14-3-3

Stable Identifier
R-HSA-482788
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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p-S54,92,203-BRF1 binds 14-3-3
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Phosphorylated BRF1 interacts with 14-3-3, becomes localized to the cytoskeleton, and no longer promotes RNA degradation. Phosphorylated BRF1 is, however, still able to bind RNA.

Literature References
PubMed ID Title Journal Year
18326031 The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2

Chou, CF, Luber, CA, Maitra, S, Chen, CY, Mann, M, Lee, KY

RNA 2008
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Orthologous Events
p-S54,92,203-BRF1 binds 14-3-3 (Bos taurus)
p-S54,92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)
p-S54,92,203-BRF1 binds 14-3-3 (Canis familiaris)
p-S54,92,203-BRF1 binds 14-3-3 (Danio rerio)
p-S54,92,203-BRF1 binds 14-3-3 (Dictyostelium discoideum)
p-S54,92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)
p-S54,92,203-BRF1 binds 14-3-3 (Gallus gallus)
p-S54,92,203-BRF1 binds 14-3-3 (Mus musculus)
p-S54,92,203-BRF1 binds 14-3-3 (Rattus norvegicus)
p-S54,92,203-BRF1 binds 14-3-3 (Sus scrofa)
p-S54,92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2010-01-29)
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