Reactome | CHRNA1 [plasma membrane]

CHRNA1 [plasma membrane]

Stable Identifier

R-HSA-480553

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Acetylcholine receptor subunit alpha, ACHA_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine Receptor (homomeric) [plasma membrane] (Homo sapiens)
        
        CHRNA1 [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine Receptor (homomeric) [plasma membrane] (Homo sapiens)
        
        CHRNA1 [plasma membrane] (Homo sapiens)
        
        O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine Receptor (homomeric) [plasma membrane] (Homo sapiens)
        
        CHRNA1 [plasma membrane] (Homo sapiens)
      - Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine Receptor (homomeric) [plasma membrane] (Homo sapiens)
        
        CHRNA1 [plasma membrane] (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Homo sapiens)
        
        0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine Receptor (homomeric) [plasma membrane] (Homo sapiens)
        
        CHRNA1 [plasma membrane] (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
        
        Acetylcholine Receptor (homomeric) [plasma membrane] (Homo sapiens)
        
        CHRNA1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02708 CHRNA1

Gene Names

CHRNA1, ACHRA, CHNRA

Chain

signal peptide:1-20, chain:21-457

Reference Genes

BioGPS Gene:1134 CHRNA1

COSMIC (genes):CHRNA1 CHRNA1

CTD Gene:1134 CHRNA1

dbSNP Gene:1134 CHRNA1

ENSEMBL:ENSG00000138435 CHRNA1

HGNC:1955 CHRNA1

KEGG:hsa:1134 CHRNA1

Monarch:1134 CHRNA1

NCBI Gene:1134 CHRNA1

OMIM:100690 CHRNA1

UCSC:P02708 CHRNA1

Reference Transcript

Other Identifiers

1134

11740288_a_at

11741163_a_at

16905273

16905289

206633_PM_at

206633_at

211039_PM_at

211039_at

2587938

2587939

2587940

2587941

2587943

2587944

2587945

2587946

2587947

2587948

2587949

2587950

2587951

2587952

2587953

2587955

2587956

2587965

2587967

2587968

2588034

2588035

34143_at

8056877

A_21_P0002119

A_23_P90888

A_24_P393458

A_33_P3365305

GE79946

GO:0003009

GO:0003012

GO:0004888

GO:0005215

GO:0005216

GO:0005230

GO:0005231

GO:0005886

GO:0005892

GO:0006811

GO:0006812

GO:0007154

GO:0007165

GO:0007268

GO:0007271

GO:0007274

GO:0007528

GO:0009986

GO:0015464

GO:0016020

GO:0019228

GO:0022848

GO:0023052

GO:0031594

GO:0034220

GO:0034330

GO:0035094

GO:0042166

GO:0042391

GO:0043005

GO:0045202

GO:0045211

GO:0046716

GO:0048630

GO:0050877

GO:0050881

GO:0050905

GO:0051899

GO:0055085

GO:0060078

GO:0060079

GO:0060089

GO:0070050

GO:0095500

GO:0099634

GO:1904315

HMNXSV003011878

HMNXSV003029999

ILMN_1798700

ILMN_2268969

ILMN_2361768

PH_hs_0020284

S77094_at

TC02002542.hg

TC02002543.hg

TC02004701.hg

TC02004702.hg

g13623428_3p_at

g4557456_3p_at

p9431

Participates

as a component of

Acetylcholine Receptor (homomeric) [plasma membrane] (Homo sapiens)

Inferred To

acr-12 [plasma membrane] (Caenorhabditis elegans)

unc-63 [plasma membrane] (Caenorhabditis elegans)

acr-8 [plasma membrane] (Caenorhabditis elegans)

lev-1 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha2 [plasma membrane] (Drosophila melanogaster)

nAChRalpha3 [plasma membrane] (Drosophila melanogaster)

unc-29 [plasma membrane] (Caenorhabditis elegans)

Chrna1 [plasma membrane] (Mus musculus)

Chrna1 [plasma membrane] (Rattus norvegicus)

acr-3 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha4 [plasma membrane] (Drosophila melanogaster)

acr-6 [plasma membrane] (Caenorhabditis elegans)

nAChRbeta2 [plasma membrane] (Drosophila melanogaster)

acr-2 [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRNA1 [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRNA1 [plasma membrane] (Drosophila melanogaster)

CHRNA1 [plasma membrane] (Bos taurus)

CHRNA1 [plasma membrane] (Canis familiaris)

CHRNA1 [plasma membrane] (Gallus gallus)

CHRNA1 [plasma membrane] (Sus scrofa)

lev-8 [plasma membrane] (Caenorhabditis elegans)

nAChRalpha1 [plasma membrane] (Drosophila melanogaster)

nAChRbeta1 [plasma membrane] (Drosophila melanogaster)

chrna1 [plasma membrane] (Danio rerio)

chrna1 [plasma membrane] (Xenopus tropicalis)

unc-38 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000070.1, NP_001034612.1

Guide to Pharmacology - Targets

462

ENSEMBL

ENSP00000261007, ENSP00000261008, ENST00000261007, ENST00000348749

OpenTargets

ENSG00000138435

ZINC - Substances

ACHA_HUMAN

ZINC target

P02708

PRO

P02708

GlyGen

P02708

PDB

4ZJS, 5HBT

HPA

ENSG00000138435-CHRNA1

Pharos - Targets

P02708

Orphanet

CHRNA1

ZINC - Predictions - Purchasable

ACHA_HUMAN