Expression of FGF2

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R-HSA-480515
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Reaction [omitted]
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Homo sapiens
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The FGF2 (bFGF) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. FGF2 is expressed in most tissues including kidney, skin, liver, ureter, and vasculature (Hughes and Hall 1993). FGF2 is expressed in about 35% of tumor lines (Chandler et al. 1999). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the FGF2 gene and POU5F1 (Babaie et al. 2007, Greber et al. 2007) and SOX2 (Greber et al. 2007) enhance transcription. The binding site of POU5F1 is adjacent to the binding site of SOX2 on the FGF2 promoter (Boyer et al. 2005). FGF2 maintains human embryonic stem cells in an undifferentiated state (Dvorak et al. 2005, Eiselleova et al. 2009).

Literature References
PubMed ID Title Journal Year
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
15955829 Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells

Dvorak, P, Dvorakova, D, Koskova, S, Vodinska, M, Najvirtova, M, Krekac, D, Hampl, A

Stem Cells 2005
19544431 A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells

Eiselleova, L, Matulka, K, Kriz, V, Kunova, M, Schmidtova, Z, Neradil, J, Tichy, B, Dvorakova, D, Pospisilova, S, Hampl, A, Dvorak, P

Stem Cells 2009
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Greber, B, Lehrach, H, Adjaye, J

BMC Dev. Biol. 2007
7688835 Immunolocalization of fibroblast growth factor receptor 1 and its ligands in human tissues

Hughes, SE, Hall, PA

Lab Invest 1993
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
10209961 Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in human tumor cell lines

Chandler, LA, Sosnowski, BA, Greenlees, L, Aukerman, SL, Baird, A, Pierce, GF

Int J Cancer 1999
9807024 Expression of fetal kidney growth factors in a kidney tumor line: role of FGF2 in kidney development

Drummond, IA, Mukhopadhyay, D, Sukhatme, VP

Exp Nephrol 1998
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