Expression of EPHA1

Stable Identifier
R-HSA-480509
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
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Expression of EPHA1
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The EPHA1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. EPHA1 is expressed most highly in epidermis of skin and is downregulated in nonmelanomal skin cancers (Hafner et al. 2006). EPHA1 is expressed at lower levels in liver, colon, small intestine, bladder, kidney, prostate, and thymus (Hafner et al. 2006). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the EPHA1 gene and OCT4 (Babaie et al. 2007, Greber et al. 2007, Kunarso et al. 2010), SOX2 (Greber et al. 2007) and NANOG (Greber et al. 2007) enhance transcription. The binding site of POU5F1 is adjacent to the binding site of SOX2 on the promoter of EPHA1 (Boyer et al. 2005). Expression and kinase activity of EPHA1 correlate with maintenance of pluripotency (Son et al. 2013).

Literature References
PubMed ID Title Journal Year
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Ng, HH, Chan, YS, Bourque, G, Chia, NY, Hwang, C, Kunarso, G, Lu, X, Jeyakani, J

Nat. Genet. 2010
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
16862074 Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer

Landthaler, M, Vogt, T, Hafner, C, Becker, B

Mod Pathol 2006
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Lehrach, H, Greber, B, Adjaye, J

BMC Dev. Biol. 2007
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Adjaye, J, Herwig, R, Burdon, T, Brink, TC, Lehrach, H, Greber, B, Wruck, W, Groth, D, Babaie, Y

Stem Cells 2007
24218367 Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency

Cho, YS, Seol, B, Son, MY, Han, YM

Hum. Mol. Genet. 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
POU5F1:SOX2:NANOG:EPHA1 gene [nucleoplasm] (Homo sapiens)
Active Unit
POU5F1 [nucleoplasm]
NANOG [nucleoplasm]
SOX2 [nucleoplasm]
Authored
May, B  (2010-11-12)
Reviewed
Wang, J  (2014-01-22)
Created
May, B  (2010-01-27)
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