Reactome | Expression of EPHA1

Expression of EPHA1

Stable Identifier

R-HSA-480509

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, plasma membrane

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The EPHA1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. EPHA1 is expressed most highly in epidermis of skin and is downregulated in nonmelanomal skin cancers (Hafner et al. 2006). EPHA1 is expressed at lower levels in liver, colon, small intestine, bladder, kidney, prostate, and thymus (Hafner et al. 2006). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the EPHA1 gene and OCT4 (Babaie et al. 2007, Greber et al. 2007, Kunarso et al. 2010), SOX2 (Greber et al. 2007) and NANOG (Greber et al. 2007) enhance transcription. The binding site of POU5F1 is adjacent to the binding site of SOX2 on the promoter of EPHA1 (Boyer et al. 2005). Expression and kinase activity of EPHA1 correlate with maintenance of pluripotency (Son et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
16153702	Core transcriptional regulatory circuitry in human embryonic stem cells Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA	Cell	2005
20526341	Transposable elements have rewired the core regulatory network of human embryonic stem cells Kunarso, G, Chia, NY, Jeyakani, J, Hwang, C, Lu, X, Chan, YS, Ng, HH, Bourque, G	Nat. Genet.	2010
16862074	Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer Hafner, C, Becker, B, Landthaler, M, Vogt, T	Mod Pathol	2006
17506876	Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal Greber, B, Lehrach, H, Adjaye, J	BMC Dev. Biol.	2007
17068183	Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J	Stem Cells	2007
24218367	Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency Son, MY, Seol, B, Han, YM, Cho, YS	Hum. Mol. Genet.	2013