Expression of ZIC3

Stable Identifier
R-HSA-480470
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of ZIC3
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The ZIC3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the ZIC3 gene and POU5F1 (Babaie et al. 2007, Greber et al. 2007) and SOX2 (Greber et al. 2007) enhances transcription. SOX2 binds adjacent to POU5F1 on the ZIC3 promoter (Boyer et al. 2005). ZIC3 is expressed in embryonic stem cells where it maintains pluripotency (Lim et al. 2007). As inferred from mouse, ZIC3 is involved in correct patterning during gastrulation (Ware et al. 2006) and mutations in ZIC3 cause heterotaxy in humans (Gebbia et al. 1997, Ware et al. 2004).

Literature References
PubMed ID Title Journal Year
14681828 Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects

Fernbach, S, Casey, B, Ware, SM, Belmont, JW, Zhu, L, Peng, J, Colicos, S, Towbin, J

Am J Hum Genet 2004
9354794 X-linked situs abnormalities result from mutations in ZIC3

Aylsworth, A, Casey, B, Burn, J, Ferrero, GB, Nelson, DL, Bassi, MT, Penman-Splitt, M, Gebbia, M, Bamforth, JS, Bird, LM, Pilia, G, Schlessinger, D

Nat Genet 1997
17267691 Zic3 is required for maintenance of pluripotency in embryonic stem cells

Lim, LS, Li, Y, Wang, Y, Loh, YH, Ng, HH, Chen, X, Bakre, M, Zhang, W, Stanton, LW

Mol Biol Cell 2007
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
16397896 Zic3 is critical for early embryonic patterning during gastrulation

Harutyunyan, KG, Ware, SM, Belmont, JW

Dev. Dyn. 2006
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Lehrach, H, Greber, B, Adjaye, J

BMC Dev. Biol. 2007
18388306 Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells

Donovan, PJ, Fong, H, Hohenstein, KA

Stem Cells 2008
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm] (Homo sapiens)
Active Unit
POU5F1 [nucleoplasm]
NANOG [nucleoplasm]
SOX2 [nucleoplasm]
Authored
May, B  (2010-01-16)
Reviewed
Wang, J  (2014-01-23)
Created
May, B  (2010-01-27)
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