Expression of ZIC3

Stable Identifier
R-HSA-480470
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The ZIC3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the ZIC3 gene and POU5F1 (Babaie et al. 2007, Greber et al. 2007) and SOX2 (Greber et al. 2007) enhances transcription. SOX2 binds adjacent to POU5F1 on the ZIC3 promoter (Boyer et al. 2005). ZIC3 is expressed in embryonic stem cells where it maintains pluripotency (Lim et al. 2007). As inferred from mouse, ZIC3 is involved in correct patterning during gastrulation (Ware et al. 2006) and mutations in ZIC3 cause heterotaxy in humans (Gebbia et al. 1997, Ware et al. 2004).

Literature References
PubMed ID Title Journal Year
9354794 X-linked situs abnormalities result from mutations in ZIC3

Gebbia, M, Ferrero, GB, Pilia, G, Bassi, MT, Aylsworth, A, Penman-Splitt, M, Bird, LM, Bamforth, JS, Burn, J, Schlessinger, D, Nelson, DL, Casey, B

Nat Genet 1997
14681828 Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects

Ware, SM, Peng, J, Zhu, L, Fernbach, S, Colicos, S, Casey, B, Towbin, J, Belmont, JW

Am J Hum Genet 2004
17267691 Zic3 is required for maintenance of pluripotency in embryonic stem cells

Lim, LS, Loh, YH, Zhang, W, Li, Y, Chen, X, Wang, Y, Bakre, M, Ng, HH, Stanton, LW

Mol Biol Cell 2007
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
16397896 Zic3 is critical for early embryonic patterning during gastrulation

Ware, SM, Harutyunyan, KG, Belmont, JW

Dev. Dyn. 2006
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Greber, B, Lehrach, H, Adjaye, J

BMC Dev. Biol. 2007
18388306 Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells

Fong, H, Hohenstein, KA, Donovan, PJ

Stem Cells 2008
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
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