POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene

Stable Identifier
R-HSA-480463
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
OCT4:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene
Summation

KLF4, PBX1, OCT4 (POU5F1), SOX2, and NANOG bind the promoter of the NANOG gene.

Literature References
PubMed ID Title Journal Year
15743839 Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression

Kuroda, T, Tada, M, Kubota, H, Kimura, H, Hatano, SY, Suemori, H, Nakatsuji, N, Tada, T

Mol Cell Biol 2005
18212089 High-throughput biochemical analysis of in vivo location data reveals novel distinct classes of POU5F1(Oct4)/DNA complexes

Tantin, D, Gemberling, M, Callister, C, Fairbrother, WG

Genome Res 2008
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
15860457 Transcriptional regulation of nanog by OCT4 and SOX2

Rodda, DJ, Chew, JL, Lim, LH, Loh, YH, Wang, B, Ng, HH, Robson, P

J Biol Chem 2005
19522013 KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells

Chan, KK, Zhang, J, Chia, NY, Chan, YS, Sim, HS, Tan, KS, Oh, SK, Ng, HH, Choo, AB

Stem Cells 2009
23178592 OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells

Navarro, P, Festuccia, N, Colby, D, Gagliardi, A, Mullin, NP, Zhang, W, Karwacki-Neisius, V, Osorno, R, Kelly, D, Robertson, M, Chambers, I

EMBO J. 2012
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Brown, S, Teo, A, Pauklin, S, Hannan, N, Cho, CH, Lim, B, Vardy, L, Dunn, NR, Trotter, M, Pedersen, R, Vallier, L

Stem Cells 2011
Participants
Participant Of
This entity regulates