Reactome | Expression of Goosecoid (GSC) in the primitive streak

Expression of Goosecoid (GSC) in the primitive streak

Stable Identifier

R-HSA-480378

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Expression of Goosecoid (GSC) in the primitive streak

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The Goosecoid (GSC) gene is transcribed to yield mRNA and the mRNA is translated to yield GSC protein. Expression of GSC is first observed in the region of the epiblast where the primitive streak forms (inferred from the mouse homolog). Expression then becomes restricted to the anterior primitive streak and the anterior midline mesoderm. Phosphorylated SMAD2 and SMAD3 in complexes with SMAD4 and TRIM33 activate transcription of GSC (inferred from mouse homologs). Beta-catenin (CTNNB1) also binds the GSC promoter and interacts with SMAD2 and SMAD3 to enhance transcription of GSC (Funa et al. 2015). GSC can bind its own promoter and downregulate expression (Danilov et al. 1998). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the GSC gene (Boyer et al. 2005), OCT4 and SOX2 repress transcription of GSC, and NANOG activates transcription of GSC in human embryonic stem cells (Babaie et al. 2007, Teo et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
9417125	Negative autoregulation of the organizer-specific homeobox gene goosecoid Danilov, V, Blum, M, Schweickert, A, Campione, M, Steinbeisser, H	J Biol Chem	1998
21245162	Pluripotency factors regulate definitive endoderm specification through eomesodermin Teo, AK, Arnold, SJ, Trotter, MW, Brown, S, Ang, LT, Chng, Z, Robertson, EJ, Dunn, NR, Vallier, L	Genes Dev.	2011
17068183	Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J	Stem Cells	2007
25921273	β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4 Funa, NS, Schachter, KA, Lerdrup, M, Ekberg, J, Hess, K, Dietrich, N, Honoré, C, Hansen, K, Semb, H	Cell Stem Cell	2015