Expression of Goosecoid (GSC) in the primitive streak

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The Goosecoid (GSC) gene is transcribed to yield mRNA and the mRNA is translated to yield GSC protein. Expression of GSC is first observed in the region of the epiblast where the primitive streak forms (inferred from the mouse homolog). Expression then becomes restricted to the anterior primitive streak and the anterior midline mesoderm. Phosphorylated SMAD2 and SMAD3 in complexes with SMAD4 and TRIM33 activate transcription of GSC (inferred from mouse homologs). Beta-catenin (CTNNB1) also binds the GSC promoter and interacts with SMAD2 and SMAD3 to enhance transcription of GSC (Funa et al. 2015). GSC can bind its own promoter and downregulate expression (Danilov et al. 1998). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the GSC gene (Boyer et al. 2005), OCT4 and SOX2 repress transcription of GSC, and NANOG activates transcription of GSC in human embryonic stem cells (Babaie et al. 2007, Teo et al. 2011).
Literature References
PubMed ID Title Journal Year
9417125 Negative autoregulation of the organizer-specific homeobox gene goosecoid

Campione, M, Blum, M, Danilov, V, Schweickert, A, Steinbeisser, H

J Biol Chem 1998
21245162 Pluripotency factors regulate definitive endoderm specification through eomesodermin

Dunn, NR, Chng, Z, Trotter, MW, Vallier, L, Teo, AK, Ang, LT, Brown, S, Arnold, SJ, Robertson, EJ

Genes Dev. 2011
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
25921273 β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4

Hess, K, Semb, H, Dietrich, N, Lerdrup, M, Funa, NS, Schachter, KA, Honoré, C, Ekberg, J, Hansen, K

Cell Stem Cell 2015
This event is regulated
Inferred From
Cite Us!