Expression of EPAS1 (HIF2A)

Stable Identifier
Reaction [omitted]
Homo sapiens
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Hypoxia causes an increase in the level of HIF3A which in turn enhances expression of EPAS1 (HIF2A). The mechanism is unknown.

The EPAS1 (HIF2A) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. EPAS1 is expressed in most adult tissues, but not in peripheral blood leukocytes (Tian et al. 1997). Normoxia causes constitutive oxygen-dependient hydroxylation of EPAS1 on asparagine and proline residues, resulting in degradation of EPAS1 via ubiquitinylation. Hypoxia therefore inhibits degradation of EPAS1 and also causes an increase in EPAS1 expression via HIF3A in embryonic stem cells, which experience hypoxic conditions in the reproductive tract prior to implantation (Forristal et al. 2010).

Literature References
PubMed ID Title Journal Year
9000051 Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

Russell, DW, Tian, H, McKnight, SL

Genes Dev 1997
19755485 Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

Houghton, FD, Forristal, CE, Oreffo, RO, Wright, KL, Hanley, NA

Reproduction 2010
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