POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter

Stable Identifier
Reaction [binding]
Homo sapiens
Formation of OCT4:SOX2:NANOG:KLF4:PBX1:SMAD2 Complex at NANOG Promoter
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

KLF4, PBX1, POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the NANOG gene and enhance expression of NANOG (Rodda et al. 2005, Boyer et al. 2005, Babaie et al. 2007, Jin et al. 2007, Chan et al. 2009, Vallier et al. 2009, Jung et al. 2011). In mouse Nanog has been shown to repress its own expression (Fidalgo et al. 2012, Navarro et al. 2012). ZIC3, a NANOG target, also positively regulates NANOG expression, possibly by binding the NANOG promoter and activating transcription (Lim et al. 2007). Activin/Nodal signaling regulates NANOG via SMAD2 and SMAD3 (Brown et al. 2011)

Literature References
PubMed ID Title Journal Year
22988117 Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming

Ding, J, Lemischka, IR, Wang, J, Silva, JC, Saunders, A, Schaniel, C, Pereira, CF, Faiola, F, Gingold, J, Fidalgo, M

Proc. Natl. Acad. Sci. U.S.A. 2012
17267691 Zic3 is required for maintenance of pluripotency in embryonic stem cells

Lim, LS, Li, Y, Wang, Y, Loh, YH, Ng, HH, Chen, X, Bakre, M, Zhang, W, Stanton, LW

Mol Biol Cell 2007
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
15860457 Transcriptional regulation of nanog by OCT4 and SOX2

Rodda, DJ, Robson, P, Lim, LH, Wang, B, Loh, YH, Ng, HH, Chew, JL

J Biol Chem 2005
19522013 KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells

Sim, HS, Chan, YS, Tan, KS, Zhang, J, Oh, SK, Chia, NY, Ng, HH, Chan, KK, Choo, AB

Stem Cells 2009
17567999 Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches

O'Geen, H, Jin, VX, Farnham, PJ, Green, R, Iyengar, S

Genome Res. 2007
19688839 Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells

Weber, A, Pedersen, RA, Vallier, L, Bilican, B, Ahrlund-Richter, L, Touboul, T, Cedervall, J, Brown, S, Cho, C, Chandran, S, Alexander, M

Stem Cells 2009
23178592 OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells

Robertson, M, Osorno, R, Gagliardi, A, Festuccia, N, Karwacki-Neisius, V, Mullin, NP, Chambers, I, Navarro, P, Zhang, W, Colby, D, Kelly, D

EMBO J. 2012
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Dunn, NR, Lim, B, Cho, CH, Vallier, L, Pedersen, R, Hannan, N, Teo, A, Vardy, L, Brown, S, Trotter, M, Pauklin, S

Stem Cells 2011
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Adjaye, J, Kahlem, P, Lehrach, H, Vilo, J, Peterson, H, Chavez, L, Jung, M

PLoS One 2010
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
Cite Us!