PIAS4 SUMOylates NR4A2 with SUMO2,3

Stable Identifier
R-HSA-4755526
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS4 SUMOylates NR4A2 with SUMO2,3
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As inferred from mouse homologs, PIAS4 SUMOylates NR4A2 (NUR1) with SUMO2,3 at lysine-558 and lysine-577. SUMOylation causes NR4A2 to interact as a monomer with the Co-REST complex and transrepress promoters of genes involved in inflammation.
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Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Physical Entity
PIAS4 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Inferred From
Pias4 Sumoylates Nr4a2 with Sumo2,3 (Mus musculus)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-25)
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